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Mesenchymal stem cell-mediated delivery boosts the efficacy of suicide gene therapy based on retroviral replicating vectors in peritoneally disseminated cancer.

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Title: Mesenchymal stem cell-mediated delivery boosts the efficacy of suicide gene therapy based on retroviral replicating vectors in peritoneally disseminated cancer.
Authors: Kubo S; Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan. s-kubo@hyo-med.ac.jp., Takeuchi Y; Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan.; Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan., Sonoda-Fukuda E; Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan., Ogawa N; Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan.; Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan., Shinoda S; Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan.; Department of Biological Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University, Sanda, Hyogo, Japan., Nakano-Doi A; Laboratory of Neural Repair and Regeneration, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan., Nakagomi T; Laboratory of Neural Repair and Regeneration, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan., Funaki S; Division of Thoracic Surgery, Department of Surgery, Hyogo Medical University, Nishinomiya, Hyogo, Japan., Kasahara N; Departments of Neurological Surgery and Radiation Oncology, University of California, San Francisco, CA, USA.
Source: Cancer gene therapy [Cancer Gene Ther] 2026 Jun 13. Date of Electronic Publication: 2026 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9432230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5500 (Electronic) Linking ISSN: 09291903 NLM ISO Abbreviation: Cancer Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mesenchymal stem cell-mediated delivery boosts the efficacy of suicide gene therapy based on retroviral replicating vectors in peritoneally disseminated cancer.
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  Data: <searchLink fieldCode="AU" term="%22Kubo+S%22">Kubo S</searchLink>; Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan. s-kubo@hyo-med.ac.jp.<br /><searchLink fieldCode="AU" term="%22Takeuchi+Y%22">Takeuchi Y</searchLink>; Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan.; Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Sonoda-Fukuda+E%22">Sonoda-Fukuda E</searchLink>; Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Ogawa+N%22">Ogawa N</searchLink>; Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan.; Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Shinoda+S%22">Shinoda S</searchLink>; Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan.; Department of Biological Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University, Sanda, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakano-Doi+A%22">Nakano-Doi A</searchLink>; Laboratory of Neural Repair and Regeneration, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagomi+T%22">Nakagomi T</searchLink>; Laboratory of Neural Repair and Regeneration, Institute for Advanced Medical Sciences, Hyogo Medical University, Nishinomiya, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Funaki+S%22">Funaki S</searchLink>; Division of Thoracic Surgery, Department of Surgery, Hyogo Medical University, Nishinomiya, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Kasahara+N%22">Kasahara N</searchLink>; Departments of Neurological Surgery and Radiation Oncology, University of California, San Francisco, CA, USA.
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  Data: <searchLink fieldCode="JN" term="%229432230%22">Cancer gene therapy</searchLink> [Cancer Gene Ther] 2026 Jun 13. <i>Date of Electronic Publication: </i>2026 Jun 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9432230 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5500 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209291903%22">09291903 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Gene Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41417-026-01047-2
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              Text: 2026 Jun 13
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