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Explainable artificial intelligence models in predicting major cardiovascular events: insights from the PolyIran and PolyPars prospective studies.

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Title: Explainable artificial intelligence models in predicting major cardiovascular events: insights from the PolyIran and PolyPars prospective studies.
Authors: Ghafari A; Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Sepanlou S; Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Roshandel G; Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran., Safavi-Naini SAA; Data Science and Machine Learning Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, Iran., Malekzadeh F; Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Sharafkhah M; Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Kasaeian A; Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Gupta A; Karsh Center of Interventional Cardiology, Smidt Heart Institute, Cedars- Sinai Medical Center, Los Angeles, CA, USA., Pawar S; Karsh Center of Interventional Cardiology, Smidt Heart Institute, Cedars- Sinai Medical Center, Los Angeles, CA, USA., Dehghanian Z; Data Science and Machine Learning Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, Iran., Azimi A; Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Aghaei M; Data Science and Machine Learning Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, Iran., Pourshams A; Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Poustchi H; Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Jahangard N; ICT Research Institute, Tehran, Iran., Rabiee HR; Data Science and Machine Learning Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, Iran. rabiee@sharif.edu., Malekzadeh R; Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. dr.reza.malekzadeh@gmail.com.; Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. dr.reza.malekzadeh@gmail.com.
Source: Scientific reports [Sci Rep] 2026 Jun 14. Date of Electronic Publication: 2026 Jun 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ghafari+A%22">Ghafari A</searchLink>; Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Sepanlou+S%22">Sepanlou S</searchLink>; Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Roshandel+G%22">Roshandel G</searchLink>; Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.<br /><searchLink fieldCode="AU" term="%22Safavi-Naini+SAA%22">Safavi-Naini SAA</searchLink>; Data Science and Machine Learning Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Malekzadeh+F%22">Malekzadeh F</searchLink>; Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Sharafkhah+M%22">Sharafkhah M</searchLink>; Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Kasaeian+A%22">Kasaeian A</searchLink>; Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Gupta+A%22">Gupta A</searchLink>; Karsh Center of Interventional Cardiology, Smidt Heart Institute, Cedars- Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pawar+S%22">Pawar S</searchLink>; Karsh Center of Interventional Cardiology, Smidt Heart Institute, Cedars- Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dehghanian+Z%22">Dehghanian Z</searchLink>; Data Science and Machine Learning Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Azimi+A%22">Azimi A</searchLink>; Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Aghaei+M%22">Aghaei M</searchLink>; Data Science and Machine Learning Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Pourshams+A%22">Pourshams A</searchLink>; Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Poustchi+H%22">Poustchi H</searchLink>; Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Jahangard+N%22">Jahangard N</searchLink>; ICT Research Institute, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Rabiee+HR%22">Rabiee HR</searchLink>; Data Science and Machine Learning Lab, Department of Computer Engineering, Sharif University of Technology, Tehran, Iran. rabiee@sharif.edu.<br /><searchLink fieldCode="AU" term="%22Malekzadeh+R%22">Malekzadeh R</searchLink>; Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. dr.reza.malekzadeh@gmail.com.; Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. dr.reza.malekzadeh@gmail.com.
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