Design and synthesis of 7-chloroquinoline-derivative-bearing urea, carbamate, or thiourea moieties and their antimalarial activity against Plasmodium berghei via the inhibition of β-hematin formation.
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| Title: | Design and synthesis of 7-chloroquinoline-derivative-bearing urea, carbamate, or thiourea moieties and their antimalarial activity against Plasmodium berghei via the inhibition of β-hematin formation. |
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| Authors: | Ramírez H; Dirección de Investigación, Universidad ECOTEC, Guayaquil, Ecuador., Mijoba AS; Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela.; Laboratory of Pathophysiology, Center for Experimental Medicine, Venezuelan Institute of Scientific Research (IVIC), Caracas, Venezuela., Espinosa S; Departamento de Química, Universidad Técnica Particular de Loja, Loja, Ecuador., Barazarte AR; Departamento de Biología y Química, Universidad Pedagógica Experimental Libertador, Caracas, Venezuela., Acosta ME; Unidad de Bioquímica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela., Charris JE; Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela., Fernandez-Moreira E; Escuela de Medicina, Universidad Espíritu Santo, Samborondón, Ecuador.; Department of Cell Biology, Complutense University School of Medicine, Madrid, Spain. |
| Source: | Frontiers in chemistry [Front Chem] 2026 May 29; Vol. 14, pp. 1827662. Date of Electronic Publication: 2026 May 29 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101627988 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2646 (Print) Linking ISSN: 22962646 NLM ISO Abbreviation: Front Chem Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2296-2646 |
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| DOI: | 10.3389/fchem.2026.1827662 |
