Design and synthesis of 7-chloroquinoline-derivative-bearing urea, carbamate, or thiourea moieties and their antimalarial activity against Plasmodium berghei via the inhibition of β-hematin formation.
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| Title: | Design and synthesis of 7-chloroquinoline-derivative-bearing urea, carbamate, or thiourea moieties and their antimalarial activity against Plasmodium berghei via the inhibition of β-hematin formation. |
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| Authors: | Ramírez H; Dirección de Investigación, Universidad ECOTEC, Guayaquil, Ecuador., Mijoba AS; Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela.; Laboratory of Pathophysiology, Center for Experimental Medicine, Venezuelan Institute of Scientific Research (IVIC), Caracas, Venezuela., Espinosa S; Departamento de Química, Universidad Técnica Particular de Loja, Loja, Ecuador., Barazarte AR; Departamento de Biología y Química, Universidad Pedagógica Experimental Libertador, Caracas, Venezuela., Acosta ME; Unidad de Bioquímica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela., Charris JE; Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela., Fernandez-Moreira E; Escuela de Medicina, Universidad Espíritu Santo, Samborondón, Ecuador.; Department of Cell Biology, Complutense University School of Medicine, Madrid, Spain. |
| Source: | Frontiers in chemistry [Front Chem] 2026 May 29; Vol. 14, pp. 1827662. Date of Electronic Publication: 2026 May 29 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101627988 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2646 (Print) Linking ISSN: 22962646 NLM ISO Abbreviation: Front Chem Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42292658 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Design and synthesis of 7-chloroquinoline-derivative-bearing urea, carbamate, or thiourea moieties and their antimalarial activity against Plasmodium berghei via the inhibition of β-hematin formation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ramírez+H%22">Ramírez H</searchLink>; Dirección de Investigación, Universidad ECOTEC, Guayaquil, Ecuador.<br /><searchLink fieldCode="AU" term="%22Mijoba+AS%22">Mijoba AS</searchLink>; Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela.; Laboratory of Pathophysiology, Center for Experimental Medicine, Venezuelan Institute of Scientific Research (IVIC), Caracas, Venezuela.<br /><searchLink fieldCode="AU" term="%22Espinosa+S%22">Espinosa S</searchLink>; Departamento de Química, Universidad Técnica Particular de Loja, Loja, Ecuador.<br /><searchLink fieldCode="AU" term="%22Barazarte+AR%22">Barazarte AR</searchLink>; Departamento de Biología y Química, Universidad Pedagógica Experimental Libertador, Caracas, Venezuela.<br /><searchLink fieldCode="AU" term="%22Acosta+ME%22">Acosta ME</searchLink>; Unidad de Bioquímica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela.<br /><searchLink fieldCode="AU" term="%22Charris+JE%22">Charris JE</searchLink>; Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela.<br /><searchLink fieldCode="AU" term="%22Fernandez-Moreira+E%22">Fernandez-Moreira E</searchLink>; Escuela de Medicina, Universidad Espíritu Santo, Samborondón, Ecuador.; Department of Cell Biology, Complutense University School of Medicine, Madrid, Spain. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101627988%22">Frontiers in chemistry</searchLink> [Front Chem] 2026 May 29; Vol. 14, pp. 1827662. <i>Date of Electronic Publication: </i>2026 May 29 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media+S%2EA%22">Frontiers Media S.A </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101627988 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2296-2646 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222962646%22">22962646 </searchLink><i>NLM ISO Abbreviation: </i>Front Chem <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42292658 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3389/fchem.2026.1827662 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1827662 Titles: – TitleFull: Design and synthesis of 7-chloroquinoline-derivative-bearing urea, carbamate, or thiourea moieties and their antimalarial activity against Plasmodium berghei via the inhibition of β-hematin formation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ramírez H – PersonEntity: Name: NameFull: Mijoba AS – PersonEntity: Name: NameFull: Espinosa S – PersonEntity: Name: NameFull: Barazarte AR – PersonEntity: Name: NameFull: Acosta ME – PersonEntity: Name: NameFull: Charris JE – PersonEntity: Name: NameFull: Fernandez-Moreira E IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 05 Text: 2026 May 29 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 2296-2646 Numbering: – Type: volume Value: 14 Titles: – TitleFull: Frontiers in chemistry Type: main |
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