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Integrated epidemiologic investigation and genomic confirmation of a Klebsiella pneumoniae neonatal sepsis outbreak in Botswana.

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Title: Integrated epidemiologic investigation and genomic confirmation of a Klebsiella pneumoniae neonatal sepsis outbreak in Botswana.
Authors: Strysko J; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.; Department of Paediatric & Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Hu W; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America., Mochankana K; Department of Paediatric & Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.; Botswana Ministry of Health and Wellness, Gaborone, Botswana., John-Thubuka J; Botswana Ministry of Health and Wellness, Gaborone, Botswana., Zankere T; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana., Gopolang B; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana., Theiller E; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.; Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America., Jones SM; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.; Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America., Tembo CV; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana., Ntereke TD; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana., Gatonye T; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana., Lechiile K; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana., Keatholetswe T; Botswana Ministry of Health and Wellness, Gaborone, Botswana., Bianco C; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America., Coffin SE; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America., McGann C; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Bittinger K; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.; Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America., Lautenbach E; Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Mannathoko N; Department of Biomedical Sciences, Faculty of Medicine, University of Botswana, Gaborone, Botswana., Mokomane M; School of Allied Health Professions, University of Botswana, Gaborone, Botswana., Mosepele M; Department of Internal Medicine, Faculty of Medicine, University of Botswana, Gaborone, Botswana., Richard-Greenblatt M; Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada., Nakstad B; Department of Paediatric & Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana., Goldfarb DM; British Columbia Children's Hospital, Vancouver, Canada., Planet PJ; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.; Comparative Genomics, American Museum of Natural HistoryNew York, New York, United States of America., Moustafa AM; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.; Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.; Department of Biomedical and Health Informatics, Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.
Source: PLOS global public health [PLOS Glob Public Health] 2026 Jun 15; Vol. 6 (6), pp. e0006468. Date of Electronic Publication: 2026 Jun 15 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 9918283779606676 Publication Model: eCollection Cited Medium: Internet ISSN: 2767-3375 (Electronic) Linking ISSN: 27673375 NLM ISO Abbreviation: PLOS Glob Public Health Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Strysko+J%22">Strysko J</searchLink>; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.; Department of Paediatric & Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Hu+W%22">Hu W</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Mochankana+K%22">Mochankana K</searchLink>; Department of Paediatric & Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.; Botswana Ministry of Health and Wellness, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22John-Thubuka+J%22">John-Thubuka J</searchLink>; Botswana Ministry of Health and Wellness, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Zankere+T%22">Zankere T</searchLink>; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Gopolang+B%22">Gopolang B</searchLink>; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Theiller+E%22">Theiller E</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.; Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Jones+SM%22">Jones SM</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.; Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Tembo+CV%22">Tembo CV</searchLink>; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Ntereke+TD%22">Ntereke TD</searchLink>; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Gatonye+T%22">Gatonye T</searchLink>; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Lechiile+K%22">Lechiile K</searchLink>; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Keatholetswe+T%22">Keatholetswe T</searchLink>; Botswana Ministry of Health and Wellness, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Bianco+C%22">Bianco C</searchLink>; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Coffin+SE%22">Coffin SE</searchLink>; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22McGann+C%22">McGann C</searchLink>; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Bittinger+K%22">Bittinger K</searchLink>; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.; Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Lautenbach+E%22">Lautenbach E</searchLink>; Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Mannathoko+N%22">Mannathoko N</searchLink>; Department of Biomedical Sciences, Faculty of Medicine, University of Botswana, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Mokomane+M%22">Mokomane M</searchLink>; School of Allied Health Professions, University of Botswana, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Mosepele+M%22">Mosepele M</searchLink>; Department of Internal Medicine, Faculty of Medicine, University of Botswana, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Richard-Greenblatt+M%22">Richard-Greenblatt M</searchLink>; Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Nakstad+B%22">Nakstad B</searchLink>; Department of Paediatric & Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Goldfarb+DM%22">Goldfarb DM</searchLink>; British Columbia Children's Hospital, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Planet+PJ%22">Planet PJ</searchLink>; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.; Comparative Genomics, American Museum of Natural HistoryNew York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Moustafa+AM%22">Moustafa AM</searchLink>; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.; Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.; Department of Biomedical and Health Informatics, Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United States of America.
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