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Inotuzumab ozogamicin in paediatric very high risk first B-cell acute lymphoblastic leukaemia relapse (ITCC-059): a multicentre, single-arm, phase 2 trial.

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Title: Inotuzumab ozogamicin in paediatric very high risk first B-cell acute lymphoblastic leukaemia relapse (ITCC-059): a multicentre, single-arm, phase 2 trial.
Authors: Peccatori N; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Locatelli F; Department of Hematology, Oncology and of Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesú, Rome, Italy; Catholic University of the Sacred Heart, Rome, Italy., Ammerlaan ACJ; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands., Jiang Y; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., van der Velden VHJ; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Netherlands., Lissat A; Department of Pediatric Oncology Hematology, Charité- Universitätsmedizin Berlin, Berlin, Germany., Nilsson A; Pediatric Oncology and Hematology, Karolinska University Hospital, Stockholm., Bielorai B; Division of Pediatric Hematology and Oncology, Sheba Medical Center, Ramat-Gan, Israel., Moerloose B; Department of Pediatric Hematology-Oncology Ghent University Hospital, Ghent, Belgium., Rives S; Institut de Recerca Sant Joan de Déu, Barcelona, Spain; Leukemia and Lymphoma Department, Pediatric Cancer Center Barcelona, Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain., Rubio-San-Simon A; Department of Pediatric Oncology and Hematology, Hospital Niño Jesús, Madrid, Spain., Dirksen U; Pediatrics III, West German Cancer Center, National Center for Tumor diseases, German Cancer Consortium, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Engstler G; St Anna Children's Hospital, Medical University of Vienna, Vienna, Austria., Bruno B; Paediatric hematology, CHU Lille, Lille, France., Diaz-de-Heredia C; Division of Pediatric Hematology and Oncology, Hospital Universitari Vall D'Hebron, Barcelona, Spain; Institut de Recerca Vall d'Hebron, Barcelona, Spain., Brethon B; Pediatric Hematology and Immunology Department, Robert Debré Academic Hospital, GHU AP-HP Nord Université Paris Cité, Paris, France., Sirvent FB; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Rialland F; Service Onco-Hématologie Pédiatrique, Hôpital Mère-Enfant, Nantes University Hospital, Nantes, France., Sramkova L; Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic., Pasquet M; Department of Pediatric Hematology, Children's Hospital, Toulouse University Hospital, Toulouse, France., Nysom K; Department of Paediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark., Bertorello N; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, University of Turin, Turin, Italy., Bader P; Department of Pediatrics, Division for Stem Cell Transplantation, Immunology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Buechner J; Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway., van der Sluis IM; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Beverloo B; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Netherlands., Sleight B; Pfizer, Groton, CT, USA., Stackelberg AV; Department of Pediatric Oncology Hematology, Charité- Universitätsmedizin Berlin, Berlin, Germany., Zwaan CM; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands., Brivio E; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. Electronic address: e.b.brivio@prinsesmaximacentrum.nl.
Source: The Lancet. Haematology [Lancet Haematol] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inotuzumab ozogamicin in paediatric very high risk first B-cell acute lymphoblastic leukaemia relapse (ITCC-059): a multicentre, single-arm, phase 2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Peccatori+N%22">Peccatori N</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Locatelli+F%22">Locatelli F</searchLink>; Department of Hematology, Oncology and of Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesú, Rome, Italy; Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ammerlaan+ACJ%22">Ammerlaan ACJ</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Velden+VHJ%22">van der Velden VHJ</searchLink>; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Lissat+A%22">Lissat A</searchLink>; Department of Pediatric Oncology Hematology, Charité- Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Nilsson+A%22">Nilsson A</searchLink>; Pediatric Oncology and Hematology, Karolinska University Hospital, Stockholm.<br /><searchLink fieldCode="AU" term="%22Bielorai+B%22">Bielorai B</searchLink>; Division of Pediatric Hematology and Oncology, Sheba Medical Center, Ramat-Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Moerloose+B%22">Moerloose B</searchLink>; Department of Pediatric Hematology-Oncology Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Rives+S%22">Rives S</searchLink>; Institut de Recerca Sant Joan de Déu, Barcelona, Spain; Leukemia and Lymphoma Department, Pediatric Cancer Center Barcelona, Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rubio-San-Simon+A%22">Rubio-San-Simon A</searchLink>; Department of Pediatric Oncology and Hematology, Hospital Niño Jesús, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Dirksen+U%22">Dirksen U</searchLink>; Pediatrics III, West German Cancer Center, National Center for Tumor diseases, German Cancer Consortium, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Engstler+G%22">Engstler G</searchLink>; St Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Bruno+B%22">Bruno B</searchLink>; Paediatric hematology, CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Diaz-de-Heredia+C%22">Diaz-de-Heredia C</searchLink>; Division of Pediatric Hematology and Oncology, Hospital Universitari Vall D'Hebron, Barcelona, Spain; Institut de Recerca Vall d'Hebron, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Brethon+B%22">Brethon B</searchLink>; Pediatric Hematology and Immunology Department, Robert Debré Academic Hospital, GHU AP-HP Nord Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sirvent+FB%22">Sirvent FB</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Rialland+F%22">Rialland F</searchLink>; Service Onco-Hématologie Pédiatrique, Hôpital Mère-Enfant, Nantes University Hospital, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Sramkova+L%22">Sramkova L</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Pasquet+M%22">Pasquet M</searchLink>; Department of Pediatric Hematology, Children's Hospital, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Nysom+K%22">Nysom K</searchLink>; Department of Paediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bertorello+N%22">Bertorello N</searchLink>; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Bader+P%22">Bader P</searchLink>; Department of Pediatrics, Division for Stem Cell Transplantation, Immunology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Buechner+J%22">Buechner J</searchLink>; Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22van+der+Sluis+IM%22">van der Sluis IM</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Beverloo+B%22">Beverloo B</searchLink>; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sleight+B%22">Sleight B</searchLink>; Pfizer, Groton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Stackelberg+AV%22">Stackelberg AV</searchLink>; Department of Pediatric Oncology Hematology, Charité- Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Zwaan+CM%22">Zwaan CM</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Brivio+E%22">Brivio E</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. Electronic address: e.b.brivio@prinsesmaximacentrum.nl.
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  Data: <searchLink fieldCode="JN" term="%22101643584%22">The Lancet. Haematology</searchLink> [Lancet Haematol] 2026 Jun 15. <i>Date of Electronic Publication: </i>2026 Jun 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101643584 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3026 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523026%22">23523026 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Haematol <i>Subsets: </i>MEDLINE
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