A fully human antibody A140 neutralizes abrin toxin via lysosomal intracellular mechanisms, confers potent protection in vitro and in vivo, and reverses transcriptomic dysregulation with a Favorable safety profile.
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| Title: | A fully human antibody A140 neutralizes abrin toxin via lysosomal intracellular mechanisms, confers potent protection in vitro and in vivo, and reverses transcriptomic dysregulation with a Favorable safety profile. |
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| Authors: | Qin F; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China., Chen SY; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China., Lin P; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China., Wang B; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China., Fu X; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China., Jiang JL; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: jiangjl@fmmu.edu.cn., Cui HY; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: cuihongyong@fmmu.edu.cn., Wang SJ; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: wangsj@fmmu.edu.cn. |
| Source: | Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2026 Jun 15; Vol. 514, pp. 117913. Date of Electronic Publication: 2026 Jun 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42297243 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A fully human antibody A140 neutralizes abrin toxin via lysosomal intracellular mechanisms, confers potent protection in vitro and in vivo, and reverses transcriptomic dysregulation with a Favorable safety profile. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Qin+F%22">Qin F</searchLink>; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+SY%22">Chen SY</searchLink>; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China.<br /><searchLink fieldCode="AU" term="%22Lin+P%22">Lin P</searchLink>; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China.<br /><searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China.<br /><searchLink fieldCode="AU" term="%22Jiang+JL%22">Jiang JL</searchLink>; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: jiangjl@fmmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Cui+HY%22">Cui HY</searchLink>; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: cuihongyong@fmmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+SJ%22">Wang SJ</searchLink>; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: wangsj@fmmu.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220416575%22">Toxicology and applied pharmacology</searchLink> [Toxicol Appl Pharmacol] 2026 Jun 15; Vol. 514, pp. 117913. <i>Date of Electronic Publication: </i>2026 Jun 15. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0416575 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-0333 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220041008X%22">0041008X </searchLink><i>NLM ISO Abbreviation: </i>Toxicol Appl Pharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42297243 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.taap.2026.117913 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 117913 Titles: – TitleFull: A fully human antibody A140 neutralizes abrin toxin via lysosomal intracellular mechanisms, confers potent protection in vitro and in vivo, and reverses transcriptomic dysregulation with a Favorable safety profile. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Qin F – PersonEntity: Name: NameFull: Chen SY – PersonEntity: Name: NameFull: Lin P – PersonEntity: Name: NameFull: Wang B – PersonEntity: Name: NameFull: Fu X – PersonEntity: Name: NameFull: Jiang JL – PersonEntity: Name: NameFull: Cui HY – PersonEntity: Name: NameFull: Wang SJ IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: 2026 Jun 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1096-0333 Numbering: – Type: volume Value: 514 Titles: – TitleFull: Toxicology and applied pharmacology Type: main |
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