A fully human antibody A140 neutralizes abrin toxin via lysosomal intracellular mechanisms, confers potent protection in vitro and in vivo, and reverses transcriptomic dysregulation with a Favorable safety profile.
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| Title: | A fully human antibody A140 neutralizes abrin toxin via lysosomal intracellular mechanisms, confers potent protection in vitro and in vivo, and reverses transcriptomic dysregulation with a Favorable safety profile. |
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| Authors: | Qin F; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China., Chen SY; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China., Lin P; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China., Wang B; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China., Fu X; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China., Jiang JL; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: jiangjl@fmmu.edu.cn., Cui HY; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: cuihongyong@fmmu.edu.cn., Wang SJ; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi'an 710032, Shaanxi, PR China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: wangsj@fmmu.edu.cn. |
| Source: | Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2026 Jun 15; Vol. 514, pp. 117913. Date of Electronic Publication: 2026 Jun 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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