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Artificial intelligence-based retinal imaging for brain health assessment: a scoping review.

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Title: Artificial intelligence-based retinal imaging for brain health assessment: a scoping review.
Authors: Ran AR; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lam Kin Chung, Jet King-Shing Ho Glaucoma Treatment and Research Centre, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China., Zhu Z; Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, Australia; Department of Surgery (Ophthalmology), University of Melbourne, Melbourne, VIC, Australia., Cheng KHL; West Suffolk NHS Foundation Trust, Cambridge, UK; Faculty of Clinical Medicine, University of Cambridge, Cambridge, UK., Ng CF; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China., Choi OYM; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China., He Q; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lam Kin Chung, Jet King-Shing Ho Glaucoma Treatment and Research Centre, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China., Zheng C; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China., Hu W; Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, Australia; Department of Surgery (Ophthalmology), University of Melbourne, Melbourne, VIC, Australia., Hu X; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China., Chan VTT; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China., Young AL; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China., Qiu K; The Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China., Eydelman MB; The Collaborative Community on Ophthalmic Innovation, Reston, VA, USA., Liu TYA; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cheng CY; Department of Ophthalmology and Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore., Tham YC; Department of Ophthalmology and Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore., Milea D; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Visual Neurosciences Lab, Rothschild Foundation Hospital, Paris, France., Wagner SK; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK; Institute of Ophthalmology, University College London, London, UK., Keane PA; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK; Institute of Ophthalmology, University College London, London, UK., Tham CC; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lam Kin Chung, Jet King-Shing Ho Glaucoma Treatment and Research Centre, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China., Ko H; Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China; Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China., Chen CL; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China., Mok VCT; Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China; Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China., Cheung CY; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lam Kin Chung, Jet King-Shing Ho Glaucoma Treatment and Research Centre, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: carolcheung@cuhk.edu.hk.
Source: The Lancet. Digital health [Lancet Digit Health] 2026 Jun 15, pp. 101020. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101751302 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-7500 (Electronic) Linking ISSN: 25897500 NLM ISO Abbreviation: Lancet Digit Health Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Artificial intelligence-based retinal imaging for brain health assessment: a scoping review.
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  Data: <searchLink fieldCode="AU" term="%22Ran+AR%22">Ran AR</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lam Kin Chung, Jet King-Shing Ho Glaucoma Treatment and Research Centre, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, Australia; Department of Surgery (Ophthalmology), University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Cheng+KHL%22">Cheng KHL</searchLink>; West Suffolk NHS Foundation Trust, Cambridge, UK; Faculty of Clinical Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ng+CF%22">Ng CF</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Choi+OYM%22">Choi OYM</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22He+Q%22">He Q</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lam Kin Chung, Jet King-Shing Ho Glaucoma Treatment and Research Centre, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Zheng+C%22">Zheng C</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Hu+W%22">Hu W</searchLink>; Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, Australia; Department of Surgery (Ophthalmology), University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Chan+VTT%22">Chan VTT</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Young+AL%22">Young AL</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Qiu+K%22">Qiu K</searchLink>; The Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.<br /><searchLink fieldCode="AU" term="%22Eydelman+MB%22">Eydelman MB</searchLink>; The Collaborative Community on Ophthalmic Innovation, Reston, VA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+TYA%22">Liu TYA</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+CY%22">Cheng CY</searchLink>; Department of Ophthalmology and Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Tham+YC%22">Tham YC</searchLink>; Department of Ophthalmology and Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Milea+D%22">Milea D</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Visual Neurosciences Lab, Rothschild Foundation Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Wagner+SK%22">Wagner SK</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK; Institute of Ophthalmology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Keane+PA%22">Keane PA</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK; Institute of Ophthalmology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tham+CC%22">Tham CC</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lam Kin Chung, Jet King-Shing Ho Glaucoma Treatment and Research Centre, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Ko+H%22">Ko H</searchLink>; Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China; Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Chen+CL%22">Chen CL</searchLink>; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+TY%22">Wong TY</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Mok+VCT%22">Mok VCT</searchLink>; Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China; Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Cheung+CY%22">Cheung CY</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lam Kin Chung, Jet King-Shing Ho Glaucoma Treatment and Research Centre, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: carolcheung@cuhk.edu.hk.
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  Data: <searchLink fieldCode="JN" term="%22101751302%22">The Lancet. Digital health</searchLink> [Lancet Digit Health] 2026 Jun 15, pp. 101020. <i>Date of Electronic Publication: </i>2026 Jun 15.
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