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DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice.

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Title: DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice.
Authors: Ding XB; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China., Li XY; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China., Zhang YY; Department of Nephrology, The Affiliated Huaian No.1 People's Hospital, Nanjing Medical University, Huai'an, 223001, China., Zhou MY; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China., Lin YW; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China., Hu WL; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China., Wu XL; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China., Li R; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China., Zhuang YL; School of Life Sciences, Xuzhou Medical University, Xuzhou, 221004, China., Zhou CH; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China. chzhou77@xzhmu.edu.cn., Wu YQ; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. xzmcyqwu@163.com.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jun 16. Date of Electronic Publication: 2026 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice.
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  Data: <searchLink fieldCode="AU" term="%22Ding+XB%22">Ding XB</searchLink>; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Li+XY%22">Li XY</searchLink>; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YY%22">Zhang YY</searchLink>; Department of Nephrology, The Affiliated Huaian No.1 People's Hospital, Nanjing Medical University, Huai'an, 223001, China.<br /><searchLink fieldCode="AU" term="%22Zhou+MY%22">Zhou MY</searchLink>; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Lin+YW%22">Lin YW</searchLink>; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Hu+WL%22">Hu WL</searchLink>; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Wu+XL%22">Wu XL</searchLink>; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Zhuang+YL%22">Zhuang YL</searchLink>; School of Life Sciences, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Zhou+CH%22">Zhou CH</searchLink>; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China. chzhou77@xzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wu+YQ%22">Wu YQ</searchLink>; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. xzmcyqwu@163.com.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Jun 16. <i>Date of Electronic Publication: </i>2026 Jun 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41401-026-01849-y
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        Text: English
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      – TitleFull: DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice.
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            – D: 16
              M: 06
              Text: 2026 Jun 16
              Type: published
              Y: 2026
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