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Runx1-Snx9 axis drives the pathological secretion of mitochondrial-derived vesicles to activate cGAS-STING signaling in acute pancreatitis.

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Title: Runx1-Snx9 axis drives the pathological secretion of mitochondrial-derived vesicles to activate cGAS-STING signaling in acute pancreatitis.
Authors: Gao M; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Xiao G; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Chen K; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Li S; Department of Immunology & Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, 510632, China., Chen C; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Yu S; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Wu Y; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Yang K; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Xie R; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.; Department of General Surgery, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University, Shanghai, 200020, China., Chen E; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.; Shanghai Institute of Aviation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Jiang J; Department of Emergency, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, No. 58, Changsheng South Road, Taicang City, Suzhou City, Jiangsu, 215400, China. 1300250699@QQ.com., Chen Y; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. bichatlion@163.com., Fei J; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. feijian@hotmail.com.; Department of General Surgery, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University, Shanghai, 200020, China. feijian@hotmail.com., Mao E; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. maoeq@yeah.net., Xu D; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. stephanie.xud@hotmail.com.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 Jun 16. Date of Electronic Publication: 2026 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Runx1-Snx9 axis drives the pathological secretion of mitochondrial-derived vesicles to activate cGAS-STING signaling in acute pancreatitis.
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  Data: <searchLink fieldCode="AU" term="%22Gao+M%22">Gao M</searchLink>; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.<br /><searchLink fieldCode="AU" term="%22Xiao+G%22">Xiao G</searchLink>; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Immunology & Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, 510632, China.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.<br /><searchLink fieldCode="AU" term="%22Yu+S%22">Yu S</searchLink>; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.<br /><searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.<br /><searchLink fieldCode="AU" term="%22Xie+R%22">Xie R</searchLink>; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.; Department of General Surgery, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University, Shanghai, 200020, China.<br /><searchLink fieldCode="AU" term="%22Chen+E%22">Chen E</searchLink>; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.; Shanghai Institute of Aviation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.<br /><searchLink fieldCode="AU" term="%22Jiang+J%22">Jiang J</searchLink>; Department of Emergency, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, No. 58, Changsheng South Road, Taicang City, Suzhou City, Jiangsu, 215400, China. 1300250699@QQ.com.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. bichatlion@163.com.<br /><searchLink fieldCode="AU" term="%22Fei+J%22">Fei J</searchLink>; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. feijian@hotmail.com.; Department of General Surgery, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University, Shanghai, 200020, China. feijian@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Mao+E%22">Mao E</searchLink>; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. maoeq@yeah.net.<br /><searchLink fieldCode="AU" term="%22Xu+D%22">Xu D</searchLink>; Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. stephanie.xud@hotmail.com.
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        Value: 10.1186/s12951-026-04687-6
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      – TitleFull: Runx1-Snx9 axis drives the pathological secretion of mitochondrial-derived vesicles to activate cGAS-STING signaling in acute pancreatitis.
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              Text: 2026 Jun 16
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