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The translational potential of drug-induced hypothermia in acute ischemic stroke.

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Title: The translational potential of drug-induced hypothermia in acute ischemic stroke.
Authors: Xu S; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China., Wang Q; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China., An H; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China., Wang H; Department of Neurology, Linyi People's Hospital, Linyi 276002, Shandong Province, China., Fang Q; Department of Anesthesia, Linyi People's Hospital, Linyi 276002, Shandong Province, China., Li T; Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China., He Q; Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China., Zhou J; Department of Neurosurgery, Affiliated Hospital to Southwest Medical University, Luzhou 646000, Sichuan Province, China., Chen J; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China., Liang Y; Department of Neurology, Linyi People's Hospital, Linyi 276002, Shandong Province, China., Jiang M; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China., Li M; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China., Zhang H; Department of Neurology, Linyi People's Hospital, Linyi 276002, Shandong Province, China., Ding Y; Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48202, USA., Li S; Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China., Che F; Department of Neurology, Linyi People's Hospital, Linyi 276002, Shandong Province, China., Wu C; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China., Ji X; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China., Wu D; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Source: Science translational medicine [Sci Transl Med] 2026 Jun 17; Vol. 18 (854), pp. eady7847. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The translational potential of drug-induced hypothermia in acute ischemic stroke.
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  Data: <searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.<br /><searchLink fieldCode="AU" term="%22An+H%22">An H</searchLink>; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Neurology, Linyi People's Hospital, Linyi 276002, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Fang+Q%22">Fang Q</searchLink>; Department of Anesthesia, Linyi People's Hospital, Linyi 276002, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22He+Q%22">He Q</searchLink>; Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Neurosurgery, Affiliated Hospital to Southwest Medical University, Luzhou 646000, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; Department of Neurology, Linyi People's Hospital, Linyi 276002, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Jiang+M%22">Jiang M</searchLink>; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Neurology, Linyi People's Hospital, Linyi 276002, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Ding+Y%22">Ding Y</searchLink>; Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48202, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.<br /><searchLink fieldCode="AU" term="%22Che+F%22">Che F</searchLink>; Department of Neurology, Linyi People's Hospital, Linyi 276002, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.<br /><searchLink fieldCode="AU" term="%22Ji+X%22">Ji X</searchLink>; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.<br /><searchLink fieldCode="AU" term="%22Wu+D%22">Wu D</searchLink>; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Jun 17; Vol. 18 (854), pp. eady7847. <i>Date of Electronic Publication: </i>2026 Jun 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1126/scitranslmed.ady7847
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              Text: 2026 Jun 17
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