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Becotatug Vedotin for Recurrent/Metastatic Nasopharyngeal Carcinoma (Magic-M001): A Multicenter, Randomized Trial.

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Title: Becotatug Vedotin for Recurrent/Metastatic Nasopharyngeal Carcinoma (Magic-M001): A Multicenter, Randomized Trial.
Authors: Han F; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China., Xiang YQ; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China., Wang XH; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China., Qu S; Department of Radiation Oncology, Guangxi Medical University Cancer Center, Nanning, China., Tang LQ; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China., Shu XL; Department of Radiation Oncology, Affiliated Tumor Hospital of Chongqing University, Chongqing, China., Zhang P; Department of Head and Neck Radiation Oncology, Sichuan Cancer Hospital, Chengdu, China., Qiu SF; Department of Head and Neck Radiation Oncology, Fujian Cancer Hospital, Fuzhou, China., Zhou YJ; Department of Head and Neck Radiation Oncology, Hunan Cancer Hospital, Changsha, China., Guo Y; Department of Radiation Oncology, Shanghai East Hospital, Shanghai, China., Xu GQ; Department of Nasopharyngeal Carcinoma Head and Neck Radiation Oncology, Zhongshan People's Hospital, Zhongshan, China., Li Q; Department of Radiation Oncology, Shanghai East Hospital, Shanghai, China., Yang KY; Department of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Du YQ; Department of Radiation Oncology, Guangxi Medical University Cancer Center, Nanning, China., Xu MJ; Department of Radiation Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China., Li JG; Department of Head and Neck Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, China., Wang F; Department of Radiation Oncology, Affiliated Tumor Hospital of Chongqing University, Chongqing, China., Huang ST; Department of Radiation Oncology, Guangxi Medical University Cancer Center, Nanning, China., Huang YJ; Department of Medical Oncology, Hainan General Hospital, Haikou, China., Wu H; Department of Radiotherapy, Henan Cancer Hospital, Zhengzhou, China., Chen XZ; Department of Head and Neck Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, China., Wei Y; Department of Oncology, Guigang People's Hospital, Guigang, China., Wu WL; Department of Head and Neck Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., Pan SM; Department of Tumor Radiotherapy, Yuebei People's Hospital, Shaoguan, China., Lin HM; Department of Oncology, Maoming People's Hospital, Maoming, China., Xiao SW; Department of Radiotherapy, Peking University Cancer Hospital, Beijing, China., Dou YW; Clinical Operation, Lepu Biopharma Co., Ltd., Beijing, China., Dai R; Clinical Operation, Lepu Biopharma Co., Ltd., Shanghai, China., Zhang P; Medical Affairs, Lepu Biopharma Co., Ltd., Beijing, China., Jin YS; Medical Affairs, Lepu Biopharma Co., Ltd., Beijing, China., Xu RH; Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, China. Electronic address: xurh@sysucc.org.cn.
Source: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE
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  Data: Becotatug Vedotin for Recurrent/Metastatic Nasopharyngeal Carcinoma (Magic-M001): A Multicenter, Randomized Trial.
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  Data: <searchLink fieldCode="AU" term="%22Han+F%22">Han F</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xiang+YQ%22">Xiang YQ</searchLink>; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+XH%22">Wang XH</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Qu+S%22">Qu S</searchLink>; Department of Radiation Oncology, Guangxi Medical University Cancer Center, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Tang+LQ%22">Tang LQ</searchLink>; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Shu+XL%22">Shu XL</searchLink>; Department of Radiation Oncology, Affiliated Tumor Hospital of Chongqing University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Department of Head and Neck Radiation Oncology, Sichuan Cancer Hospital, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Qiu+SF%22">Qiu SF</searchLink>; Department of Head and Neck Radiation Oncology, Fujian Cancer Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+YJ%22">Zhou YJ</searchLink>; Department of Head and Neck Radiation Oncology, Hunan Cancer Hospital, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Department of Radiation Oncology, Shanghai East Hospital, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+GQ%22">Xu GQ</searchLink>; Department of Nasopharyngeal Carcinoma Head and Neck Radiation Oncology, Zhongshan People's Hospital, Zhongshan, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Radiation Oncology, Shanghai East Hospital, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yang+KY%22">Yang KY</searchLink>; Department of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Du+YQ%22">Du YQ</searchLink>; Department of Radiation Oncology, Guangxi Medical University Cancer Center, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Xu+MJ%22">Xu MJ</searchLink>; Department of Radiation Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+JG%22">Li JG</searchLink>; Department of Head and Neck Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Radiation Oncology, Affiliated Tumor Hospital of Chongqing University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Huang+ST%22">Huang ST</searchLink>; Department of Radiation Oncology, Guangxi Medical University Cancer Center, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Huang+YJ%22">Huang YJ</searchLink>; Department of Medical Oncology, Hainan General Hospital, Haikou, China.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Department of Radiotherapy, Henan Cancer Hospital, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+XZ%22">Chen XZ</searchLink>; Department of Head and Neck Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wei+Y%22">Wei Y</searchLink>; Department of Oncology, Guigang People's Hospital, Guigang, China.<br /><searchLink fieldCode="AU" term="%22Wu+WL%22">Wu WL</searchLink>; Department of Head and Neck Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China.<br /><searchLink fieldCode="AU" term="%22Pan+SM%22">Pan SM</searchLink>; Department of Tumor Radiotherapy, Yuebei People's Hospital, Shaoguan, China.<br /><searchLink fieldCode="AU" term="%22Lin+HM%22">Lin HM</searchLink>; Department of Oncology, Maoming People's Hospital, Maoming, China.<br /><searchLink fieldCode="AU" term="%22Xiao+SW%22">Xiao SW</searchLink>; Department of Radiotherapy, Peking University Cancer Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Dou+YW%22">Dou YW</searchLink>; Clinical Operation, Lepu Biopharma Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Dai+R%22">Dai R</searchLink>; Clinical Operation, Lepu Biopharma Co., Ltd., Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Medical Affairs, Lepu Biopharma Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Jin+YS%22">Jin YS</searchLink>; Medical Affairs, Lepu Biopharma Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+RH%22">Xu RH</searchLink>; Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, China. Electronic address: xurh@sysucc.org.cn.
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  Data: <searchLink fieldCode="JN" term="%229007735%22">Annals of oncology : official journal of the European Society for Medical Oncology</searchLink> [Ann Oncol] 2026 Jun 17. <i>Date of Electronic Publication: </i>2026 Jun 17.
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