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Integration and validation of complementary ex vivo assays for functional precision oncology.

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Title: Integration and validation of complementary ex vivo assays for functional precision oncology.
Authors: Loboda A; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Paluncic J; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Freitas M; PreComb AG, Hombrechtikon, Switzerland., Weidmann M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Herter S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Zeiser C; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Faculty of Medicine, Heidelberg University, Heidelberg, Germany., Schulz JP; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Jády A; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Blattner-Johnson M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Autry RJ; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Frese K; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany., Lupar D; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Soft-tissue sarcoma research group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schneider M; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany., Imle R; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Soft-tissue sarcoma research group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany., Banito A; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Soft-tissue sarcoma research group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Glimm H; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; Translational Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), partner site Dresden, Dresden, Germany., Witt O; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany., Peterziel H; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Kelm JM; PreComb AG, Hombrechtikon, Switzerland., Ball CR; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; German Cancer Consortium (DKTK), partner site Dresden, Dresden, Germany.; Faculty of Biology, TUD Dresden University of Technology, Dresden, Germany., Oehme I; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. i.oehme@kitz-heidelberg.de.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. i.oehme@kitz-heidelberg.de.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. i.oehme@kitz-heidelberg.de.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany. i.oehme@kitz-heidelberg.de.
Source: NPJ precision oncology [NPJ Precis Oncol] 2026 Jun 17; Vol. 10 (1). Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Integration and validation of complementary ex vivo assays for functional precision oncology.
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  Data: <searchLink fieldCode="AU" term="%22Loboda+A%22">Loboda A</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Paluncic+J%22">Paluncic J</searchLink>; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Freitas+M%22">Freitas M</searchLink>; PreComb AG, Hombrechtikon, Switzerland.<br /><searchLink fieldCode="AU" term="%22Weidmann+M%22">Weidmann M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Herter+S%22">Herter S</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zeiser+C%22">Zeiser C</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Faculty of Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schulz+JP%22">Schulz JP</searchLink>; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Jády+A%22">Jády A</searchLink>; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Blattner-Johnson+M%22">Blattner-Johnson M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Autry+RJ%22">Autry RJ</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Frese+K%22">Frese K</searchLink>; German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lupar+D%22">Lupar D</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Soft-tissue sarcoma research group, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+M%22">Schneider M</searchLink>; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Imle+R%22">Imle R</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Soft-tissue sarcoma research group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Banito+A%22">Banito A</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Soft-tissue sarcoma research group, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Glimm+H%22">Glimm H</searchLink>; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; Translational Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), partner site Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Witt+O%22">Witt O</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Peterziel+H%22">Peterziel H</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kelm+JM%22">Kelm JM</searchLink>; PreComb AG, Hombrechtikon, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ball+CR%22">Ball CR</searchLink>; Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; German Cancer Consortium (DKTK), partner site Dresden, Dresden, Germany.; Faculty of Biology, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Oehme+I%22">Oehme I</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. i.oehme@kitz-heidelberg.de.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. i.oehme@kitz-heidelberg.de.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. i.oehme@kitz-heidelberg.de.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany. i.oehme@kitz-heidelberg.de.
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              Text: 2026 Jun 17
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