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15-LOX-catalytic bias towards ether-(alkenyl)-ETE-PEs oxidation bestows selectivity of PRO-ferroptotic cell death signaling.

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Title: 15-LOX-catalytic bias towards ether-(alkenyl)-ETE-PEs oxidation bestows selectivity of PRO-ferroptotic cell death signaling.
Authors: Tyurina YY; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA., Mikulska-Ruminska K; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Torun, Poland., Tyurin VA; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA., Kleiboeker BA; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA., Kapralov AA; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA., Hashimoto A; AstraZeneca, ICC, Early Oncology R&D, Gaithersburg, MD, USA., Sparvero LJ; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA., Dar HH; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA., Akdogan M; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA., Yamada K; Department of Respiratory Medicine, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Zhao J; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA., Kelestemur T; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Children's Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Saritas E; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Children's Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Samovich SN; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Children's Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Holman TR; Department of Chemistry and Biochemistry University of California Santa Cruz, Santa Cruz, CA, USA., Bunimovich YL; Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Nefedova Y; The Wistar Institute, Philadelphia, PA, USA., Gabrilovich DI; AstraZeneca, ICC, Early Oncology R&D, Gaithersburg, MD, USA., Wenzel SE; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA., Bahar I; Laufer Center for Physical and Quantitative Biology, Stony Brook University, New York, NY, USA.; Department of Biochemistry & Cell Biology, Renaissance School of Medicine, and Department of Chemistry, College of Arts & Sciences, Stony Brook University, Stony Brook, NY, USA., Kagan VE; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA. kagan@pitt.edu.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA. kagan@pitt.edu.; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Children's Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA. kagan@pitt.edu., Bayır H; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Children's Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA. hb2753@cumc.columbia.edu.
Source: Nature communications [Nat Commun] 2026 Jun 17; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: 15-LOX-catalytic bias towards ether-(alkenyl)-ETE-PEs oxidation bestows selectivity of PRO-ferroptotic cell death signaling.
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  Data: <searchLink fieldCode="AU" term="%22Tyurina+YY%22">Tyurina YY</searchLink>; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mikulska-Ruminska+K%22">Mikulska-Ruminska K</searchLink>; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Torun, Poland.<br /><searchLink fieldCode="AU" term="%22Tyurin+VA%22">Tyurin VA</searchLink>; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kleiboeker+BA%22">Kleiboeker BA</searchLink>; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kapralov+AA%22">Kapralov AA</searchLink>; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hashimoto+A%22">Hashimoto A</searchLink>; AstraZeneca, ICC, Early Oncology R&D, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sparvero+LJ%22">Sparvero LJ</searchLink>; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dar+HH%22">Dar HH</searchLink>; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Akdogan+M%22">Akdogan M</searchLink>; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yamada+K%22">Yamada K</searchLink>; Department of Respiratory Medicine, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kelestemur+T%22">Kelestemur T</searchLink>; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Children's Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Saritas+E%22">Saritas E</searchLink>; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Children's Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Samovich+SN%22">Samovich SN</searchLink>; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Children's Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Holman+TR%22">Holman TR</searchLink>; Department of Chemistry and Biochemistry University of California Santa Cruz, Santa Cruz, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bunimovich+YL%22">Bunimovich YL</searchLink>; Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Nefedova+Y%22">Nefedova Y</searchLink>; The Wistar Institute, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gabrilovich+DI%22">Gabrilovich DI</searchLink>; AstraZeneca, ICC, Early Oncology R&D, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wenzel+SE%22">Wenzel SE</searchLink>; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bahar+I%22">Bahar I</searchLink>; Laufer Center for Physical and Quantitative Biology, Stony Brook University, New York, NY, USA.; Department of Biochemistry & Cell Biology, Renaissance School of Medicine, and Department of Chemistry, College of Arts & Sciences, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kagan+VE%22">Kagan VE</searchLink>; Department of Environmental and Occupational Health, School of Public Health, Pittsburgh, PA, USA. kagan@pitt.edu.; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA. kagan@pitt.edu.; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Children's Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA. kagan@pitt.edu.<br /><searchLink fieldCode="AU" term="%22Bayır+H%22">Bayır H</searchLink>; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Children's Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA. hb2753@cumc.columbia.edu.
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