Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease.

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Title: Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease.
Authors: Sheshadri P; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK. preethi.sheshadri@ukdri.ac.uk.; UK Dementia Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK. preethi.sheshadri@ukdri.ac.uk., Costa-Besada MA; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK.; Research Centre for Molecular Medicine and Chronic Diseases (CIMUS), Research Health Institute of Santiago (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.; Networking Research Centre on Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Fisher A; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK., Kiraly S; UCL Institute of Ophthalmology, Bath Street, London, EC1V9EL, UK., Singh K; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK., Kourouzidou I; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK.; Biofabics, Rua do Campo Lindo, Porto, Portugal., Blacker TS; Department of Structural and Molecular Biology, UCL, London, WC1E 6BT, UK., Zeng J; Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA, 02215, USA.; Department of Biomedical and Chemical Engineering, Syracuse University, New York, USA., Shirihai OS; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Grinstaff MW; Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA, 02215, USA., Duchen MR; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK. m.duchen@ucl.ac.uk.
Source: Translational neurodegeneration [Transl Neurodegener] 2026 Jun 17; Vol. 15 (1). Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101591861 Publication Model: Electronic Cited Medium: Print ISSN: 2047-9158 (Print) Linking ISSN: 20479158 NLM ISO Abbreviation: Transl Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2047-9158
DOI:10.1186/s40035-026-00559-z