Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease.
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| Title: | Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease. |
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| Authors: | Sheshadri P; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK. preethi.sheshadri@ukdri.ac.uk.; UK Dementia Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK. preethi.sheshadri@ukdri.ac.uk., Costa-Besada MA; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK.; Research Centre for Molecular Medicine and Chronic Diseases (CIMUS), Research Health Institute of Santiago (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.; Networking Research Centre on Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Fisher A; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK., Kiraly S; UCL Institute of Ophthalmology, Bath Street, London, EC1V9EL, UK., Singh K; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK., Kourouzidou I; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK.; Biofabics, Rua do Campo Lindo, Porto, Portugal., Blacker TS; Department of Structural and Molecular Biology, UCL, London, WC1E 6BT, UK., Zeng J; Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA, 02215, USA.; Department of Biomedical and Chemical Engineering, Syracuse University, New York, USA., Shirihai OS; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Grinstaff MW; Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA, 02215, USA., Duchen MR; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK. m.duchen@ucl.ac.uk. |
| Source: | Translational neurodegeneration [Transl Neurodegener] 2026 Jun 17; Vol. 15 (1). Date of Electronic Publication: 2026 Jun 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101591861 Publication Model: Electronic Cited Medium: Print ISSN: 2047-9158 (Print) Linking ISSN: 20479158 NLM ISO Abbreviation: Transl Neurodegener Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42310725 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Sheshadri+P%22">Sheshadri P</searchLink>; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK. preethi.sheshadri@ukdri.ac.uk.; UK Dementia Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK. preethi.sheshadri@ukdri.ac.uk.<br /><searchLink fieldCode="AU" term="%22Costa-Besada+MA%22">Costa-Besada MA</searchLink>; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK.; Research Centre for Molecular Medicine and Chronic Diseases (CIMUS), Research Health Institute of Santiago (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.; Networking Research Centre on Neurodegenerative Diseases (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fisher+A%22">Fisher A</searchLink>; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Kiraly+S%22">Kiraly S</searchLink>; UCL Institute of Ophthalmology, Bath Street, London, EC1V9EL, UK.<br /><searchLink fieldCode="AU" term="%22Singh+K%22">Singh K</searchLink>; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Kourouzidou+I%22">Kourouzidou I</searchLink>; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK.; Biofabics, Rua do Campo Lindo, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Blacker+TS%22">Blacker TS</searchLink>; Department of Structural and Molecular Biology, UCL, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Zeng+J%22">Zeng J</searchLink>; Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA, 02215, USA.; Department of Biomedical and Chemical Engineering, Syracuse University, New York, USA.<br /><searchLink fieldCode="AU" term="%22Shirihai+OS%22">Shirihai OS</searchLink>; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Grinstaff+MW%22">Grinstaff MW</searchLink>; Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Duchen+MR%22">Duchen MR</searchLink>; Department of Cell and Developmental Biology, University College London, UCL Consortium for Mitochondrial Research, London, WC1E 6BT, UK. m.duchen@ucl.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101591861%22">Translational neurodegeneration</searchLink> [Transl Neurodegener] 2026 Jun 17; Vol. 15 (1). <i>Date of Electronic Publication: </i>2026 Jun 17. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101591861 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2047-9158 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220479158%22">20479158 </searchLink><i>NLM ISO Abbreviation: </i>Transl Neurodegener <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42310725 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s40035-026-00559-z Languages: – Code: eng Text: English Titles: – TitleFull: Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sheshadri P – PersonEntity: Name: NameFull: Costa-Besada MA – PersonEntity: Name: NameFull: Fisher A – PersonEntity: Name: NameFull: Kiraly S – PersonEntity: Name: NameFull: Singh K – PersonEntity: Name: NameFull: Kourouzidou I – PersonEntity: Name: NameFull: Blacker TS – PersonEntity: Name: NameFull: Zeng J – PersonEntity: Name: NameFull: Shirihai OS – PersonEntity: Name: NameFull: Grinstaff MW – PersonEntity: Name: NameFull: Duchen MR IsPartOfRelationships: – BibEntity: Dates: – D: 17 M: 06 Text: 2026 Jun 17 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 2047-9158 Numbering: – Type: volume Value: 15 – Type: issue Value: 1 Titles: – TitleFull: Translational neurodegeneration Type: main |
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