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Impact of PD-1+Tim-3+CD8+ T cells in pretreatment tumors on chemotherapy responses in esophageal cancer.

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Title: Impact of PD-1+Tim-3+CD8+ T cells in pretreatment tumors on chemotherapy responses in esophageal cancer.
Authors: Sumimoto T; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan., Yamamoto K; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan., Saito T; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan. saitou.takurou.med@osaka-u.ac.jp.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan. saitou.takurou.med@osaka-u.ac.jp., Urakawa S; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan., Takeoka T; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan., Makino T; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan., Kurokawa Y; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan., Kawashima A; Department of Urology, Graduate School of Medicine, The University of Osaka, 2-2, Yamada-oka, Suita, Osaka, 565-0871, Japan., Ueyama A; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan.; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd, Toyonaka, Japan., Eguchi H; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan., Doki Y; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan., Wada H; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Jun 18. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
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  Data: Impact of PD-1<superscript>+</superscript>Tim-3<superscript>+</superscript>CD8<superscript>+</superscript> T cells in pretreatment tumors on chemotherapy responses in esophageal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Sumimoto+T%22">Sumimoto T</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+K%22">Yamamoto K</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+T%22">Saito T</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan. saitou.takurou.med@osaka-u.ac.jp.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan. saitou.takurou.med@osaka-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Urakawa+S%22">Urakawa S</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Takeoka+T%22">Takeoka T</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Makino+T%22">Makino T</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Kurokawa+Y%22">Kurokawa Y</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Kawashima+A%22">Kawashima A</searchLink>; Department of Urology, Graduate School of Medicine, The University of Osaka, 2-2, Yamada-oka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Ueyama+A%22">Ueyama A</searchLink>; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan.; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd, Toyonaka, Japan.<br /><searchLink fieldCode="AU" term="%22Eguchi+H%22">Eguchi H</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Doki+Y%22">Doki Y</searchLink>; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-oka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Wada+H%22">Wada H</searchLink>; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, 2-2-0803B, Yamada-oka, Suita, Osaka, 565-0871, Japan.
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              Text: 2026 Jun 18
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