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Association between initial benzodiazepine prescribing patterns and time to benzodiazepine discontinuation: A population-based retrospective cohort study.

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Title: Association between initial benzodiazepine prescribing patterns and time to benzodiazepine discontinuation: A population-based retrospective cohort study.
Authors: Bozinoff N; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Deparent of Family and Community Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Hauck TS; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Kleinman RA; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Sloan ME; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Department of Psychological Clinical Science, University of Toronto Scarborough, Toronto, Ontario, Canada., Sproule BA; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Vigod SN; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto, Ontario, Canada.; Department of Psychiatry, Women's College Hospital and Women's College Hospital Research and Innovation Institute, Toronto, Ontario, Canada., Wyman J; Deparent of Family and Community Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, Women's College Hospital, Toronto, Ontario, Canada., Pequeno P; ICES, Toronto, Ontario, Canada., Gomes T; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Source: PLoS medicine [PLoS Med] 2026 Jun 18; Vol. 23 (6), pp. e1005126. Date of Electronic Publication: 2026 Jun 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101231360 Publication Model: eCollection Cited Medium: Internet ISSN: 1549-1676 (Electronic) Linking ISSN: 15491277 NLM ISO Abbreviation: PLoS Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Association between initial benzodiazepine prescribing patterns and time to benzodiazepine discontinuation: A population-based retrospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Bozinoff+N%22">Bozinoff N</searchLink>; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Deparent of Family and Community Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hauck+TS%22">Hauck TS</searchLink>; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kleinman+RA%22">Kleinman RA</searchLink>; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Sloan+ME%22">Sloan ME</searchLink>; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Department of Psychological Clinical Science, University of Toronto Scarborough, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Sproule+BA%22">Sproule BA</searchLink>; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Vigod+SN%22">Vigod SN</searchLink>; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto, Ontario, Canada.; Department of Psychiatry, Women's College Hospital and Women's College Hospital Research and Innovation Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wyman+J%22">Wyman J</searchLink>; Deparent of Family and Community Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, Women's College Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pequeno+P%22">Pequeno P</searchLink>; ICES, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Gomes+T%22">Gomes T</searchLink>; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
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              Text: 2026 Jun 18
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