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Effectiveness and implementation of a primary healthcare intervention for multimorbidity and frailty among urban older adults in India: Protocol for the Multi-FrAME cluster randomized trial.

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Title: Effectiveness and implementation of a primary healthcare intervention for multimorbidity and frailty among urban older adults in India: Protocol for the Multi-FrAME cluster randomized trial.
Authors: Kshatri JS; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.; Maastricht University, The Netherlands., Bhattacharya H; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India., Goutam S; IMS and SUM Hospital-II, Phulnakhra, Bhubaneswar, India., Mahakuda AK; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India., Nayak R; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India., Adukkadukam Kambikanam K; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India., Rehman T; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India., Sinha A; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India., Sahu MM; Swami Vivekanand National Institute of Rehabilitation Training and Research (SVNIRTAR), Cuttack, India., Mohakud K; Swami Vivekanand National Institute of Rehabilitation Training and Research (SVNIRTAR), Cuttack, India., Das PC; SUM Ultimate Medicare Hospital, Bhubaneswar, India., Pati S; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.; Indian Council of Medical Research Centre, (Department of Health Research, Ministry of Health and Family Welfare, Government of India), New Delhi, India.
Source: PloS one [PLoS One] 2026 Jun 18; Vol. 21 (6), pp. e0351110. Date of Electronic Publication: 2026 Jun 18 (Print Publication: 2026).
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effectiveness and implementation of a primary healthcare intervention for multimorbidity and frailty among urban older adults in India: Protocol for the Multi-FrAME cluster randomized trial.
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  Data: <searchLink fieldCode="AU" term="%22Kshatri+JS%22">Kshatri JS</searchLink>; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.; Maastricht University, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bhattacharya+H%22">Bhattacharya H</searchLink>; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India.<br /><searchLink fieldCode="AU" term="%22Goutam+S%22">Goutam S</searchLink>; IMS and SUM Hospital-II, Phulnakhra, Bhubaneswar, India.<br /><searchLink fieldCode="AU" term="%22Mahakuda+AK%22">Mahakuda AK</searchLink>; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India.<br /><searchLink fieldCode="AU" term="%22Nayak+R%22">Nayak R</searchLink>; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India.<br /><searchLink fieldCode="AU" term="%22Adukkadukam+Kambikanam+K%22">Adukkadukam Kambikanam K</searchLink>; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India.<br /><searchLink fieldCode="AU" term="%22Rehman+T%22">Rehman T</searchLink>; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India.<br /><searchLink fieldCode="AU" term="%22Sinha+A%22">Sinha A</searchLink>; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India.<br /><searchLink fieldCode="AU" term="%22Sahu+MM%22">Sahu MM</searchLink>; Swami Vivekanand National Institute of Rehabilitation Training and Research (SVNIRTAR), Cuttack, India.<br /><searchLink fieldCode="AU" term="%22Mohakud+K%22">Mohakud K</searchLink>; Swami Vivekanand National Institute of Rehabilitation Training and Research (SVNIRTAR), Cuttack, India.<br /><searchLink fieldCode="AU" term="%22Das+PC%22">Das PC</searchLink>; SUM Ultimate Medicare Hospital, Bhubaneswar, India.<br /><searchLink fieldCode="AU" term="%22Pati+S%22">Pati S</searchLink>; ICMR-Regional Medical Research Centre (Department of Health Research, Ministry of Health and Family Welfare, Government of India), Chandrasekharpur, Bhubaneswar, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.; Indian Council of Medical Research Centre, (Department of Health Research, Ministry of Health and Family Welfare, Government of India), New Delhi, India.
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