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PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.

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Title: PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.
Authors: He H; University of Macau Hangzhou, Zhejiang China., Hu Y; Zhejiang Cancer Hospital China., Lu Y; Hangzhou Institute of Medicine, Chinese Academy of Sciences Hangzhou China., Deng M; Zhejiang Cancer Hospital China., Bao Q; Zhejiang Cancer Hospital hangzhou China., Zu D; Zhejiang Cancer Hospital hangzhou China., Zhong Y; Wenzhou Medical University China., Zhang C; Zhejiang Cancer Hospital hangzhou China., You C; Zhejiang Cancer Hospital China., Du X; Zhejiang Cancer Hospital hangzhou China., Liu S; Zhejiang Cancer Hospital hangzhou China., He Y; Zhejiang Cancer Hospital China., Liu M; The University of Texas MD Anderson Cancer Center Houston, TX United States., Gao L; University of Macau Macau China., Gao X; University of Macau Macau China., Liu H; Zhejiang Cancer Hospital hangzhou China., Huang Y; Zhejiang University hangzhou China., Chen Y; University of Macau Macau China., Rong D; University of Macau Macau China., Tainer JA; The University of Texas MD Anderson Cancer Center Houston, TX United States., Jing J; Zhejiang Cancer Hospital Hangzhou China., Shi Y; Zhejiang University China., Shen HM; University of Macau Macau China., Ye Z; Zhejiang Cancer Hospital Hangzhou China., Cheng X; Zhejiang Cancer Hospital Hangzhou, Zhejiang China.
Source: Cancer research [Cancer Res] 2026 Jun 18. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.
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  Data: <searchLink fieldCode="AU" term="%22He+H%22">He H</searchLink>; University of Macau Hangzhou, Zhejiang China.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Zhejiang Cancer Hospital China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Hangzhou Institute of Medicine, Chinese Academy of Sciences Hangzhou China.<br /><searchLink fieldCode="AU" term="%22Deng+M%22">Deng M</searchLink>; Zhejiang Cancer Hospital China.<br /><searchLink fieldCode="AU" term="%22Bao+Q%22">Bao Q</searchLink>; Zhejiang Cancer Hospital hangzhou China.<br /><searchLink fieldCode="AU" term="%22Zu+D%22">Zu D</searchLink>; Zhejiang Cancer Hospital hangzhou China.<br /><searchLink fieldCode="AU" term="%22Zhong+Y%22">Zhong Y</searchLink>; Wenzhou Medical University China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Zhejiang Cancer Hospital hangzhou China.<br /><searchLink fieldCode="AU" term="%22You+C%22">You C</searchLink>; Zhejiang Cancer Hospital China.<br /><searchLink fieldCode="AU" term="%22Du+X%22">Du X</searchLink>; Zhejiang Cancer Hospital hangzhou China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Zhejiang Cancer Hospital hangzhou China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Zhejiang Cancer Hospital China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; The University of Texas MD Anderson Cancer Center Houston, TX United States.<br /><searchLink fieldCode="AU" term="%22Gao+L%22">Gao L</searchLink>; University of Macau Macau China.<br /><searchLink fieldCode="AU" term="%22Gao+X%22">Gao X</searchLink>; University of Macau Macau China.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Zhejiang Cancer Hospital hangzhou China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Zhejiang University hangzhou China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; University of Macau Macau China.<br /><searchLink fieldCode="AU" term="%22Rong+D%22">Rong D</searchLink>; University of Macau Macau China.<br /><searchLink fieldCode="AU" term="%22Tainer+JA%22">Tainer JA</searchLink>; The University of Texas MD Anderson Cancer Center Houston, TX United States.<br /><searchLink fieldCode="AU" term="%22Jing+J%22">Jing J</searchLink>; Zhejiang Cancer Hospital Hangzhou China.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Zhejiang University China.<br /><searchLink fieldCode="AU" term="%22Shen+HM%22">Shen HM</searchLink>; University of Macau Macau China.<br /><searchLink fieldCode="AU" term="%22Ye+Z%22">Ye Z</searchLink>; Zhejiang Cancer Hospital Hangzhou China.<br /><searchLink fieldCode="AU" term="%22Cheng+X%22">Cheng X</searchLink>; Zhejiang Cancer Hospital Hangzhou, Zhejiang China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2984705R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7445 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200085472%22">00085472 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1158/0008-5472.CAN-25-4984
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              Text: 2026 Jun 18
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