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Hierarchical composite outcomes in acute ischaemic stroke with large infarct: a win ratio analysis of the TENSION trial.

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Title: Hierarchical composite outcomes in acute ischaemic stroke with large infarct: a win ratio analysis of the TENSION trial.
Authors: Ciobanu-Caraus O; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Heesen P; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.; Department of Biostatistics at the Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland., Hill MD; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Health Science Centre, University of Calgary & Foothills Medical Centre, Calgary, Alberta, Canada., Bonekamp S; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Fiehler J; Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.; Eppdata GmbH, Hamburg, Germany., Aamodt AH; Department of Neurology, Oslo University Hospital, Oslo, Norway., Fuentes B; Department of Neurology and Stroke Centre, Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Madrid, Spain., Gizewski ER; Department of Radiology, Medical University Innsbruck, Innsbruck, Austria., Krajina A; Department of Radiology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Pierot L; Department of Neuroradiology, Hôpital Maison-Blanche, Université Reims-Champagne-Ardenne, Reims, France., Simonsen CZ; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark., Zeleňák K; Clinic of Radiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia., Blauenfeldt RA; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark., Cheng B; Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Denis A; Service deBiostatistique, Hospices Civils de Lyon, Lyon, France.; Laboratoire de Biométrie et Biologie Évolutive, Université de Lyon, Villeurbanne, France., Deutschmann H; Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University Graz, Graz, Austria., Dorn F; Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum Bonn, Bonn, Germany., Flottmann F; Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Gellißen S; Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Gerber JC; Institute of Neuroradiology, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany.; Dresden Neurovascular Center, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany., Goyal M; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Health Science Centre, University of Calgary & Foothills Medical Centre, Calgary, Alberta, Canada., Haring J; Department of Neurology, Faculty Hospital Trnava, Trnava, Slovakia., Herweh C; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Hopf-Jensen S; Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, DIAKO Krankenhaus gGmbH, Flensburg, Germany., Hua VT; Department of Neuroradiology, Hôpital Maison-Blanche, Université Reims-Champagne-Ardenne, Reims, France., Jensen M; Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Kastrup A; Klinik für Neurologie, Klinikum Bremen Mitte, Bremen, Germany., Keil CF; Institut für Neuroradiologie, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany., Klepanec A; Department of Radiology, Faculty Hospital Trnava, Trnava, Slovakia., Kurča E; Clinic of Neurology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia., Mikkelsen R; Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark., Müller-Hülsbeck S; Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, DIAKO Krankenhaus gGmbH, Flensburg, Germany., Münnich N; Klinikum Dortmund gGmbH, Klinikum der Universität Witten/Herdecke, Dortmund, Germany., Pagano P; Department of Neuroradiology, Hôpital Maison-Blanche, Université Reims-Champagne-Ardenne, Reims, France., Papanagiotou P; Klinik für Diagnostische und Interventionelle Neuroradiologie, Klinikum Bremen Mitte, Bremen, Germany.; Department of Radiology, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Petzold GC; Vascular Neurology Research Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Division of Vascular Neurology, Department of Neurology, University Hospital Bonn, Bonn, Germany., Pham M; Institut für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum Würzburg, Würzburg, Germany., Puetz V; Dresden Neurovascular Center, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany.; Department of Neurology, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany., Raupach J; Department of Radiology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Reimann G; Klinikum Dortmund gGmbH, Klinikum der Universität Witten/Herdecke, Dortmund, Germany., Ringleb PA; Neurologie, Universitätsklinikum Heidelberg, Heidelberg, Germany., Schell M; Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Schlemm E; Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Schönenberger S; Neurologie, Universitätsklinikum Heidelberg, Heidelberg, Germany., Tennøe B; Department of Neuroradiology, Oslo University Hospital, Oslo, Norway., Ulfert C; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Vališ K; Department of Medical Imaging, St. Anne's University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Vítková E; Department of Neurology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Vollherbst DF; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Wick W; Neurologie, Universitätsklinikum Heidelberg, Heidelberg, Germany., Thomalla G; Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Möhlenbruch M; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Bendszus M; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Corporate Authors: TENSION Investigators
Source: European stroke journal [Eur Stroke J] 2026 Jun 02; Vol. 11 (6).
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: SAGE Publications Ltd Country of Publication: England NLM ID: 101688446 Publication Model: Print Cited Medium: Internet ISSN: 2396-9881 (Electronic) Linking ISSN: 23969873 NLM ISO Abbreviation: Eur Stroke J Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Hierarchical composite outcomes in acute ischaemic stroke with large infarct: a win ratio analysis of the TENSION trial.
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  Data: <searchLink fieldCode="AU" term="%22Ciobanu-Caraus+O%22">Ciobanu-Caraus O</searchLink>; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Heesen+P%22">Heesen P</searchLink>; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.; Department of Biostatistics at the Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hill+MD%22">Hill MD</searchLink>; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Health Science Centre, University of Calgary & Foothills Medical Centre, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Bonekamp+S%22">Bonekamp S</searchLink>; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Fiehler+J%22">Fiehler J</searchLink>; Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.; Eppdata GmbH, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Aamodt+AH%22">Aamodt AH</searchLink>; Department of Neurology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Fuentes+B%22">Fuentes B</searchLink>; Department of Neurology and Stroke Centre, Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gizewski+ER%22">Gizewski ER</searchLink>; Department of Radiology, Medical University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Krajina+A%22">Krajina A</searchLink>; Department of Radiology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Pierot+L%22">Pierot L</searchLink>; Department of Neuroradiology, Hôpital Maison-Blanche, Université Reims-Champagne-Ardenne, Reims, France.<br /><searchLink fieldCode="AU" term="%22Simonsen+CZ%22">Simonsen CZ</searchLink>; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Zeleňák+K%22">Zeleňák K</searchLink>; Clinic of Radiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.<br /><searchLink fieldCode="AU" term="%22Blauenfeldt+RA%22">Blauenfeldt RA</searchLink>; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Cheng+B%22">Cheng B</searchLink>; Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Denis+A%22">Denis A</searchLink>; Service deBiostatistique, Hospices Civils de Lyon, Lyon, France.; Laboratoire de Biométrie et Biologie Évolutive, Université de Lyon, Villeurbanne, France.<br /><searchLink fieldCode="AU" term="%22Deutschmann+H%22">Deutschmann H</searchLink>; Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Dorn+F%22">Dorn F</searchLink>; Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Flottmann+F%22">Flottmann F</searchLink>; Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gellißen+S%22">Gellißen S</searchLink>; Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gerber+JC%22">Gerber JC</searchLink>; Institute of Neuroradiology, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany.; Dresden Neurovascular Center, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Goyal+M%22">Goyal M</searchLink>; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Health Science Centre, University of Calgary & Foothills Medical Centre, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Haring+J%22">Haring J</searchLink>; Department of Neurology, Faculty Hospital Trnava, Trnava, Slovakia.<br /><searchLink fieldCode="AU" term="%22Herweh+C%22">Herweh C</searchLink>; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hopf-Jensen+S%22">Hopf-Jensen S</searchLink>; Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, DIAKO Krankenhaus gGmbH, Flensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hua+VT%22">Hua VT</searchLink>; Department of Neuroradiology, Hôpital Maison-Blanche, Université Reims-Champagne-Ardenne, Reims, France.<br /><searchLink fieldCode="AU" term="%22Jensen+M%22">Jensen M</searchLink>; Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kastrup+A%22">Kastrup A</searchLink>; Klinik für Neurologie, Klinikum Bremen Mitte, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Keil+CF%22">Keil CF</searchLink>; 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Neurologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Thomalla+G%22">Thomalla G</searchLink>; Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Möhlenbruch+M%22">Möhlenbruch M</searchLink>; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bendszus+M%22">Bendszus M</searchLink>; Interventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
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            NameFull: Schlemm E
      – PersonEntity:
          Name:
            NameFull: Schönenberger S
      – PersonEntity:
          Name:
            NameFull: Tennøe B
      – PersonEntity:
          Name:
            NameFull: Ulfert C
      – PersonEntity:
          Name:
            NameFull: Vališ K
      – PersonEntity:
          Name:
            NameFull: Vítková E
      – PersonEntity:
          Name:
            NameFull: Vollherbst DF
      – PersonEntity:
          Name:
            NameFull: Wick W
      – PersonEntity:
          Name:
            NameFull: Thomalla G
      – PersonEntity:
          Name:
            NameFull: Möhlenbruch M
      – PersonEntity:
          Name:
            NameFull: Bendszus M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 06
              Text: 2026 Jun 02
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2396-9881
          Numbering:
            – Type: volume
              Value: 11
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: European stroke journal
              Type: main
ResultId 1