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Bisphosphonate zoledronic acid blocks secretory autophagy and inhibits bone resorptive functions in osteoclasts.

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Title: Bisphosphonate zoledronic acid blocks secretory autophagy and inhibits bone resorptive functions in osteoclasts.
Authors: Kim S; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Division of Preventive and Restorative Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.; Section of Biosystems and Function, UCLA School of Dentistry, Los Angeles, CA, USA., Goldshteyn V; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Division of Preventive and Restorative Sciences, UCLA School of Dentistry, Los Angeles, CA, USA., Arai A; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Institute for Oral Science, Department of Orthodontics, Matsumoto Dental University, Nagano, Japan., Bae EB; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Division of Preventive and Restorative Sciences, UCLA School of Dentistry, Los Angeles, CA, USA., Whitelegge J; The Pasarow Mass Spectrometry Laboratory, the Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA David Geffen School of Medicine, Los Angeles, CA, USA., Shin KH; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Section of Biosystems and Function, UCLA School of Dentistry, Los Angeles, CA, USA., Park NH; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.; UCLA David Geffen School of Medicine, Los Angeles, CA, USA., Kim RH; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Division of Preventive and Restorative Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.; Section of Biosystems and Function, UCLA School of Dentistry, Los Angeles, CA, USA.; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
Source: Autophagy [Autophagy] 2026 Jun 28, pp. 1-13. Date of Electronic Publication: 2026 Jun 28.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE
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  Data: Bisphosphonate zoledronic acid blocks secretory autophagy and inhibits bone resorptive functions in osteoclasts.
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  Data: <searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Division of Preventive and Restorative Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.; Section of Biosystems and Function, UCLA School of Dentistry, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Goldshteyn+V%22">Goldshteyn V</searchLink>; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Division of Preventive and Restorative Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Arai+A%22">Arai A</searchLink>; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Institute for Oral Science, Department of Orthodontics, Matsumoto Dental University, Nagano, Japan.<br /><searchLink fieldCode="AU" term="%22Bae+EB%22">Bae EB</searchLink>; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Division of Preventive and Restorative Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Whitelegge+J%22">Whitelegge J</searchLink>; The Pasarow Mass Spectrometry Laboratory, the Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shin+KH%22">Shin KH</searchLink>; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Section of Biosystems and Function, UCLA School of Dentistry, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Park+NH%22">Park NH</searchLink>; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.; UCLA David Geffen School of Medicine, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+RH%22">Kim RH</searchLink>; The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.; Division of Preventive and Restorative Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.; Section of Biosystems and Function, UCLA School of Dentistry, Los Angeles, CA, USA.; UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
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              Text: 2026 Jun 28
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