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Disease modification in advanced Parkinson's disease: a review and roadmap for paving the way for next-generation interventions.

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Title: Disease modification in advanced Parkinson's disease: a review and roadmap for paving the way for next-generation interventions.
Authors: Groppa S; Department of Neurology, Saarland University Medical Center, Homburg, Germany. Sergiu.Groppa@uks.eu., Fasano A; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele, Milan, Italy.; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy., Urso D; Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', Bari, Italy., Yang X; Department of Neurology, Saarland University Medical Center, Homburg, Germany., Popescu B; Department of Neurology, School of Medicine, Colentina Clinical Hospital, 'Carol Davila' University of Medicine, Bucharest, Romania., Klivenyi P; Department of Neurology, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary., van Laar T; Department of Neurology, University of Groningen, Groningen, Netherlands., Jost W; Department of Neurology, Saarland University Medical Center, Homburg, Germany.; Parkinson Clinic Ortenau, Wolfach, Germany., Garcia-Ruiz PJ; Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain., Bhidayasiri R; Chulalongkorn Centre of Excellence for Parkinson's Disease and Related Disorders, Department of Medicine, Faculty of Medicine, Thai Red Cross Society, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; The Academy of Science, The Royal Society of Thailand, Bangkok, Thailand.; Chulalongkorn Centre of Excellence for Parkinson's Disease & Related Disorders, Chulalongkorn University Hospital, 1873 Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand., Outeiro TF; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37073, Göttingen, Germany.; Algarve Biomedical Center Research Institute (ABC-Ri), Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 8005-139, Faro, Portugal.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Source: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2026 Jun 19. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 9702341 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1463 (Electronic) Linking ISSN: 03009564 NLM ISO Abbreviation: J Neural Transm (Vienna) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Disease modification in advanced Parkinson's disease: a review and roadmap for paving the way for next-generation interventions.
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  Data: <searchLink fieldCode="AU" term="%22Groppa+S%22">Groppa S</searchLink>; Department of Neurology, Saarland University Medical Center, Homburg, Germany. Sergiu.Groppa@uks.eu.<br /><searchLink fieldCode="AU" term="%22Fasano+A%22">Fasano A</searchLink>; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele, Milan, Italy.; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Urso+D%22">Urso D</searchLink>; Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Neurology, Saarland University Medical Center, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Popescu+B%22">Popescu B</searchLink>; Department of Neurology, School of Medicine, Colentina Clinical Hospital, 'Carol Davila' University of Medicine, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Klivenyi+P%22">Klivenyi P</searchLink>; Department of Neurology, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22van+Laar+T%22">van Laar T</searchLink>; Department of Neurology, University of Groningen, Groningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Jost+W%22">Jost W</searchLink>; Department of Neurology, Saarland University Medical Center, Homburg, Germany.; Parkinson Clinic Ortenau, Wolfach, Germany.<br /><searchLink fieldCode="AU" term="%22Garcia-Ruiz+PJ%22">Garcia-Ruiz PJ</searchLink>; Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Bhidayasiri+R%22">Bhidayasiri R</searchLink>; Chulalongkorn Centre of Excellence for Parkinson's Disease and Related Disorders, Department of Medicine, Faculty of Medicine, Thai Red Cross Society, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; The Academy of Science, The Royal Society of Thailand, Bangkok, Thailand.; Chulalongkorn Centre of Excellence for Parkinson's Disease & Related Disorders, Chulalongkorn University Hospital, 1873 Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand.<br /><searchLink fieldCode="AU" term="%22Outeiro+TF%22">Outeiro TF</searchLink>; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37073, Göttingen, Germany.; Algarve Biomedical Center Research Institute (ABC-Ri), Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 8005-139, Faro, Portugal.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
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  Data: <searchLink fieldCode="JN" term="%229702341%22">Journal of neural transmission (Vienna, Austria : 1996)</searchLink> [J Neural Transm (Vienna)] 2026 Jun 19. <i>Date of Electronic Publication: </i>2026 Jun 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Austria <i>NLM ID: </i>9702341 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1435-1463 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203009564%22">03009564 </searchLink><i>NLM ISO Abbreviation: </i>J Neural Transm (Vienna) <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 19
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