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Persistent CD4+ T cell hyporesponsiveness during recovery from prolonged symptomatic SARS-CoV-2 infection.

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Title: Persistent CD4+ T cell hyporesponsiveness during recovery from prolonged symptomatic SARS-CoV-2 infection.
Authors: Ziegler J; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA., Lawrence C; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA., Pezant N; Center for Biomedical Data Sciences, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA., Turner S; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA., Redinger N; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA., Guthridge C; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA., Smith K; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA., Chen J; Cell Cycle and Cancer Biology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA., Guthridge JM; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA., James JA; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Microbiology & Immunology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA., Rankin S; Cell Cycle and Cancer Biology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Cell Biology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA., Thompson LF; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Microbiology & Immunology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA., Farris AD; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Microbiology & Immunology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA. Electronic address: Darise-Farris@omrf.org., Kovats S; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Microbiology & Immunology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA. Electronic address: Susan-Kovats@omrf.org.
Source: Cellular immunology [Cell Immunol] 2026 Jun 15; Vol. 426, pp. 105127. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1246405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2163 (Electronic) Linking ISSN: 00088749 NLM ISO Abbreviation: Cell Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Persistent CD4<superscript>+</superscript> T cell hyporesponsiveness during recovery from prolonged symptomatic SARS-CoV-2 infection.
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  Data: <searchLink fieldCode="AU" term="%22Ziegler+J%22">Ziegler J</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Lawrence+C%22">Lawrence C</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Pezant+N%22">Pezant N</searchLink>; Center for Biomedical Data Sciences, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Turner+S%22">Turner S</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Redinger+N%22">Redinger N</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Guthridge+C%22">Guthridge C</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Smith+K%22">Smith K</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Cell Cycle and Cancer Biology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Guthridge+JM%22">Guthridge JM</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22James+JA%22">James JA</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Microbiology & Immunology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Rankin+S%22">Rankin S</searchLink>; Cell Cycle and Cancer Biology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Cell Biology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+LF%22">Thompson LF</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Microbiology & Immunology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Farris+AD%22">Farris AD</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Microbiology & Immunology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA. Electronic address: Darise-Farris@omrf.org.<br /><searchLink fieldCode="AU" term="%22Kovats+S%22">Kovats S</searchLink>; Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, USA; Department of Microbiology & Immunology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Campus, 1100 N Lindsay Ave, Oklahoma City, OK, USA. Electronic address: Susan-Kovats@omrf.org.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>1246405 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2163 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200088749%22">00088749 </searchLink><i>NLM ISO Abbreviation: </i>Cell Immunol <i>Subsets: </i>MEDLINE
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