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Amyloid-β1-42 oligomers compromise oligodendrocyte precursor cells and disrupt blood-brain barrier integrity in vitro.

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Title: Amyloid-β1-42 oligomers compromise oligodendrocyte precursor cells and disrupt blood-brain barrier integrity in vitro.
Authors: Toyokawa M; Human Health Science, Graduate School of Medicine, Kyoto University, Japan; Department of Clinical Nursing, Shiga University of Medical Science, Japan., Yasuda K; Department of Neurology, Kyoto University Graduate School of Medicine, Japan., Kikuya A; Department of Neurology, Kyoto University Graduate School of Medicine, Japan., Asada-Utsugi M; Human Health Science, Graduate School of Medicine, Kyoto University, Japan; Department of Neurology, Molecular Neuroscience Research Center, Shiga University of Medical Science, Japan., Hida M; Human Health Science, Graduate School of Medicine, Kyoto University, Japan., Nakamura Y; Department of Neurology, Kyoto University Graduate School of Medicine, Japan., Yanagida N; Department of Neurology, Kyoto University Graduate School of Medicine, Japan., Toda S; Department of Neurology, Kyoto University Graduate School of Medicine, Japan., Kaji S; Department of Neurology, Kyoto University Graduate School of Medicine, Japan., Kinoshita Y; Concept Creation Technology Humanized Preclinical Models Department, Eisai Co., Ltd, Japan., Ono Y; Concept Creation Technology Humanized Preclinical Models Department, Eisai Co., Ltd, Japan., Takahashi R; Department of Neurology, Kyoto University Graduate School of Medicine, Japan., Matsumoto R; Department of Neurology, Kyoto University Graduate School of Medicine, Japan., Kinosita A; Human Health Science, Graduate School of Medicine, Kyoto University, Japan., Maki T; Department of Neurology, Kyoto University Graduate School of Medicine, Japan. Electronic address: harutoma@kuhp.kyoto-u.ac.jp.
Source: Brain research [Brain Res] 2026 Jun 19, pp. 150436. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Toyokawa+M%22">Toyokawa M</searchLink>; Human Health Science, Graduate School of Medicine, Kyoto University, Japan; Department of Clinical Nursing, Shiga University of Medical Science, Japan.<br /><searchLink fieldCode="AU" term="%22Yasuda+K%22">Yasuda K</searchLink>; Department of Neurology, Kyoto University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Kikuya+A%22">Kikuya A</searchLink>; Department of Neurology, Kyoto University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Asada-Utsugi+M%22">Asada-Utsugi M</searchLink>; Human Health Science, Graduate School of Medicine, Kyoto University, Japan; Department of Neurology, Molecular Neuroscience Research Center, Shiga University of Medical Science, Japan.<br /><searchLink fieldCode="AU" term="%22Hida+M%22">Hida M</searchLink>; Human Health Science, Graduate School of Medicine, Kyoto University, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+Y%22">Nakamura Y</searchLink>; Department of Neurology, Kyoto University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Yanagida+N%22">Yanagida N</searchLink>; Department of Neurology, Kyoto University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Toda+S%22">Toda S</searchLink>; Department of Neurology, Kyoto University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Kaji+S%22">Kaji S</searchLink>; Department of Neurology, Kyoto University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Kinoshita+Y%22">Kinoshita Y</searchLink>; Concept Creation Technology Humanized Preclinical Models Department, Eisai Co., Ltd, Japan.<br /><searchLink fieldCode="AU" term="%22Ono+Y%22">Ono Y</searchLink>; Concept Creation Technology Humanized Preclinical Models Department, Eisai Co., Ltd, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+R%22">Takahashi R</searchLink>; Department of Neurology, Kyoto University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Matsumoto+R%22">Matsumoto R</searchLink>; Department of Neurology, Kyoto University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Kinosita+A%22">Kinosita A</searchLink>; Human Health Science, Graduate School of Medicine, Kyoto University, Japan.<br /><searchLink fieldCode="AU" term="%22Maki+T%22">Maki T</searchLink>; Department of Neurology, Kyoto University Graduate School of Medicine, Japan. Electronic address: harutoma@kuhp.kyoto-u.ac.jp.
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