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DNA methylation-based classification uncovers acinar and ductal origins for KPC-derived PDAC cell lines.

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Title: DNA methylation-based classification uncovers acinar and ductal origins for KPC-derived PDAC cell lines.
Authors: Zoi I; Université catholique de Louvain, de Duve Institute, Brussels, Belgium. Electronic address: ilianna.zoi@uclouvain.be., Rajput M; Université catholique de Louvain, de Duve Institute, Brussels, Belgium., Holguín-Horcajo A; Pancreas Regeneration: Pancreatic Progenitors and Their Niche Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain; Department of Physiological Science, School of Medicine, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain., Haidar M; Université catholique de Louvain, de Duve Institute, Brussels, Belgium., Brusa D; CytoFlux-IREC Flow Cytometry Platform, Université catholique de Louvain, Institute for Experimental and Clinical Research, Brussels, Belgium., Chu K; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada., Xie J; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shields M; Department of Pathology and Stony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Ferreira SM; Departments of Radiation Oncology and Genetics, Stanford University School of Medicine, Stanford, CA, USA., Stanger B; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Attardi LD; Departments of Radiation Oncology and Genetics, Stanford University School of Medicine, Stanford, CA, USA., Kopp J; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada., Stemmler MP; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany., Nicolle R; Université Paris Cité, Centre de Recherche Sur L'Inflammation (CRI), INSERM, U1149, Paris, France., Rovira M; Pancreas Regeneration: Pancreatic Progenitors and Their Niche Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain; Department of Physiological Science, School of Medicine, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain., Jacquemin P; Université catholique de Louvain, de Duve Institute, Brussels, Belgium. Electronic address: patrick.jacquemin@uclouvain.be.
Source: Cancer letters [Cancer Lett] 2026 Jun 19; Vol. 656, pp. 218666. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DNA methylation-based classification uncovers acinar and ductal origins for KPC-derived PDAC cell lines.
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  Data: <searchLink fieldCode="AU" term="%22Zoi+I%22">Zoi I</searchLink>; Université catholique de Louvain, de Duve Institute, Brussels, Belgium. Electronic address: ilianna.zoi@uclouvain.be.<br /><searchLink fieldCode="AU" term="%22Rajput+M%22">Rajput M</searchLink>; Université catholique de Louvain, de Duve Institute, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Holguín-Horcajo+A%22">Holguín-Horcajo A</searchLink>; Pancreas Regeneration: Pancreatic Progenitors and Their Niche Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain; Department of Physiological Science, School of Medicine, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Haidar+M%22">Haidar M</searchLink>; Université catholique de Louvain, de Duve Institute, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Brusa+D%22">Brusa D</searchLink>; CytoFlux-IREC Flow Cytometry Platform, Université catholique de Louvain, Institute for Experimental and Clinical Research, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Chu+K%22">Chu K</searchLink>; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shields+M%22">Shields M</searchLink>; Department of Pathology and Stony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ferreira+SM%22">Ferreira SM</searchLink>; Departments of Radiation Oncology and Genetics, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Stanger+B%22">Stanger B</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Attardi+LD%22">Attardi LD</searchLink>; Departments of Radiation Oncology and Genetics, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kopp+J%22">Kopp J</searchLink>; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Stemmler+MP%22">Stemmler MP</searchLink>; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Nicolle+R%22">Nicolle R</searchLink>; Université Paris Cité, Centre de Recherche Sur L'Inflammation (CRI), INSERM, U1149, Paris, France.<br /><searchLink fieldCode="AU" term="%22Rovira+M%22">Rovira M</searchLink>; Pancreas Regeneration: Pancreatic Progenitors and Their Niche Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain; Department of Physiological Science, School of Medicine, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Jacquemin+P%22">Jacquemin P</searchLink>; Université catholique de Louvain, de Duve Institute, Brussels, Belgium. Electronic address: patrick.jacquemin@uclouvain.be.
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  Data: <searchLink fieldCode="JN" term="%227600053%22">Cancer letters</searchLink> [Cancer Lett] 2026 Jun 19; Vol. 656, pp. 218666. <i>Date of Electronic Publication: </i>2026 Jun 19.
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