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Blood IL-6 is a critical trigger of depressive symptoms in a mouse model for human atopic dermatitis.

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Title: Blood IL-6 is a critical trigger of depressive symptoms in a mouse model for human atopic dermatitis.
Authors: Matsuda K; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.; Division of Allergy and Clinical Immunology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Muko R; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan., Moon C; College of Veterinary Medicine and Veterinary Medical Research Institute, Chonnam National University, Gwangju, South Korea., Shin T; College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, Jeju Special Self-Governing Province, South Korea., Arkwright PD; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom., Pennock JL; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom., Endo S; Aging Neuroscience Research Team, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Yanai S; Animal Facility, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Jensen-Jarolim E; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, and the interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University of Vienna, Vienna, Austria., Shibuya A; Department of Immunology, Institute of Medicine and R&D Center for Innovative Drug Discovery, University of Tsukuba, Ibaraki, Japan., Tominaga M; Juntendo Itch Research Center, Institute for Environmental and Gender-specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan., Takamori K; Juntendo Itch Research Center, Institute for Environmental and Gender-specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan., Oikawa MA; Diagnostic Laboratory, Equine Veterinary Medical Center, Education City, Doha, Qatar., Tanaka A; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan. akane@cc.tuat.ac.jp., Matsuda H; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan. hiro@cc.tuat.ac.jp.
Source: Translational psychiatry [Transl Psychiatry] 2026 Jun 20. Date of Electronic Publication: 2026 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Matsuda+K%22">Matsuda K</searchLink>; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.; Division of Allergy and Clinical Immunology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Muko+R%22">Muko R</searchLink>; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Moon+C%22">Moon C</searchLink>; College of Veterinary Medicine and Veterinary Medical Research Institute, Chonnam National University, Gwangju, South Korea.<br /><searchLink fieldCode="AU" term="%22Shin+T%22">Shin T</searchLink>; College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, Jeju Special Self-Governing Province, South Korea.<br /><searchLink fieldCode="AU" term="%22Arkwright+PD%22">Arkwright PD</searchLink>; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pennock+JL%22">Pennock JL</searchLink>; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Endo+S%22">Endo S</searchLink>; Aging Neuroscience Research Team, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yanai+S%22">Yanai S</searchLink>; Animal Facility, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Jensen-Jarolim+E%22">Jensen-Jarolim E</searchLink>; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, and the interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Shibuya+A%22">Shibuya A</searchLink>; Department of Immunology, Institute of Medicine and R&D Center for Innovative Drug Discovery, University of Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Tominaga+M%22">Tominaga M</searchLink>; Juntendo Itch Research Center, Institute for Environmental and Gender-specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Takamori+K%22">Takamori K</searchLink>; Juntendo Itch Research Center, Institute for Environmental and Gender-specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Oikawa+MA%22">Oikawa MA</searchLink>; Diagnostic Laboratory, Equine Veterinary Medical Center, Education City, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Tanaka+A%22">Tanaka A</searchLink>; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan. akane@cc.tuat.ac.jp.<br /><searchLink fieldCode="AU" term="%22Matsuda+H%22">Matsuda H</searchLink>; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan. hiro@cc.tuat.ac.jp.
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              Text: 2026 Jun 20
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