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Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome.

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Title: Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome.
Authors: Nguyen ST; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine, Irvine, CA, USA., Watson RL; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Medicine, Pulmonary and Critical Care Section, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA., Gao F; Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, Gavin Hebert Eye Institute, University of California Irvine, Irvine, CA, USA., Campos M; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA., Jung S; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA., Seabrook LJ; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA., Kim MC; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA., Hanse EA; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA., Yang Y; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA., Kong M; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA., Zuckerman JE; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Pereira RC; Department of Pediatrics, Division of Nephrology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Salusky IB; Department of Pediatrics, Division of Nephrology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Catz SD; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA, USA., Jang C; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA.; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA, USA., Skowronska-Krawczyk D; Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, Gavin Hebert Eye Institute, University of California Irvine, Irvine, CA, USA.; Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA., Albrecht LV; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine, Irvine, CA, USA. l.albrecht@uci.edu.; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA. l.albrecht@uci.edu.
Source: Nature cell biology [Nat Cell Biol] 2026 Jun 19. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Nguyen+ST%22">Nguyen ST</searchLink>; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Watson+RL%22">Watson RL</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Medicine, Pulmonary and Critical Care Section, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gao+F%22">Gao F</searchLink>; Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, Gavin Hebert Eye Institute, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Campos+M%22">Campos M</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jung+S%22">Jung S</searchLink>; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Seabrook+LJ%22">Seabrook LJ</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+MC%22">Kim MC</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hanse+EA%22">Hanse EA</searchLink>; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kong+M%22">Kong M</searchLink>; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zuckerman+JE%22">Zuckerman JE</searchLink>; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pereira+RC%22">Pereira RC</searchLink>; Department of Pediatrics, Division of Nephrology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Salusky+IB%22">Salusky IB</searchLink>; Department of Pediatrics, Division of Nephrology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Catz+SD%22">Catz SD</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jang+C%22">Jang C</searchLink>; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA.; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Skowronska-Krawczyk+D%22">Skowronska-Krawczyk D</searchLink>; Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, Gavin Hebert Eye Institute, University of California Irvine, Irvine, CA, USA.; Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Albrecht+LV%22">Albrecht LV</searchLink>; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine, Irvine, CA, USA. l.albrecht@uci.edu.; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, CA, USA. l.albrecht@uci.edu.
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