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Functional Outcome Prediction in Young Adults With Mental Health Symptoms Using Machine Learning and Large Language Models: Longitudinal Observational Study.

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Title: Functional Outcome Prediction in Young Adults With Mental Health Symptoms Using Machine Learning and Large Language Models: Longitudinal Observational Study.
Authors: Mikolas P; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.; Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, Jena, Thuringia, 07743, Germany, 49 36419300., Huth F; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Bröckel-Bundt K; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Berndt C; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Martini J; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Maicher B; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Marxen M; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Verhees FG; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Henneberg PM; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Vogelbacher C; Department of Psychiatry, University of Marburg, Marburg, Germany.; Core-Facility Brain Imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany., Jansen A; Department of Psychiatry, University of Marburg, Marburg, Germany.; Core-Facility Brain Imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany., Kircher T; Department of Psychiatry, University of Marburg, Marburg, Germany.; Core-Facility Brain Imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany., Falkenberg I; Department of Psychiatry, University of Marburg, Marburg, Germany.; Core-Facility Brain Imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany., Thomas-Odenthal F; Department of Psychiatry, University of Marburg, Marburg, Germany.; Core-Facility Brain Imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany., Lambert M; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kraft V; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Leicht G; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mulert C; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Centre for Psychiatry, Justus-Liebig University Giessen, Giessen, Germany., Fallgatter AJ; Tübingen Center for Mental Health, Department of Psychiatry, University of Tübingen, Tübingen, Baden-Wurttemberg, Germany.; Partner Site Tübingen, Deutsches Zentrum für Psychische Gesundheit, Tübingen, Germany., Ethofer T; Tübingen Center for Mental Health, Department of Psychiatry, University of Tübingen, Tübingen, Baden-Wurttemberg, Germany.; Partner Site Tübingen, Deutsches Zentrum für Psychische Gesundheit, Tübingen, Germany.; Biomedical Magnetic Resonance, University of Tübingen, Tuebingen, Baden-Wurttemberg, Germany., Rau A; Tübingen Center for Mental Health, Department of Psychiatry, University of Tübingen, Tübingen, Baden-Wurttemberg, Germany., Leopold K; Vivantes Hospital Am Urban and Vivantes Hospital Im Friedrichshain, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany., Bechdolf A; Vivantes Hospital Am Urban and Vivantes Hospital Im Friedrichshain, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany., Andreas R; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University Frankfurt, Frankfurt, Germany., Matura S; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University Frankfurt, Frankfurt, Germany., Repple J; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.; Cooperative Brain Imaging Center - CoBIC, Goethe University Frankfurt, Frankfurt, Hesse, Germany.; Institute for Translational Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany., Bermpohl F; Charité Campus Mitte, Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany., Fiebig J; Charité Campus Mitte, Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany., Stamm T; Charité Campus Mitte, Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.; Department of Clinical Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Brandenburg, Germany., Correll CU; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.; Department of Psychiatry, Northwell Health, Zucker Hillside Hospital, New York, NY, United States.; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States., Juckel G; Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr-University, Bochum, Germany., Flasbeck V; Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr-University, Bochum, Germany., Wiest IC; Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany., Kather JN; Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Bielefeld University, Bielefeld, Germany.; German Center for Mental Health (DZPG), Jena Magdeburg Halle, Germany.; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Jena Magdeburg Halle, Germany., Mennigen E; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Ritter P; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Bauer M; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany., Pfennig A; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.
Source: JMIR mental health [JMIR Ment Health] 2026 Jun 22; Vol. 13, pp. e84424. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: JMIR Publications Inc Country of Publication: Canada NLM ID: 101658926 Publication Model: Electronic Cited Medium: Internet ISSN: 2368-7959 (Electronic) Linking ISSN: 23687959 NLM ISO Abbreviation: JMIR Ment Health Subsets: MEDLINE
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  Data: Functional Outcome Prediction in Young Adults With Mental Health Symptoms Using Machine Learning and Large Language Models: Longitudinal Observational Study.
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  Data: <searchLink fieldCode="AU" term="%22Mikolas+P%22">Mikolas P</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.; Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, Jena, Thuringia, 07743, Germany, 49 36419300.<br /><searchLink fieldCode="AU" term="%22Huth+F%22">Huth F</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Bröckel-Bundt+K%22">Bröckel-Bundt K</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Berndt+C%22">Berndt C</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Martini+J%22">Martini J</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Maicher+B%22">Maicher B</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Marxen+M%22">Marxen M</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Verhees+FG%22">Verhees FG</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Henneberg+PM%22">Henneberg PM</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Vogelbacher+C%22">Vogelbacher C</searchLink>; Department of Psychiatry, University of Marburg, Marburg, Germany.; Core-Facility Brain Imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Jansen+A%22">Jansen A</searchLink>; Department of Psychiatry, University of Marburg, Marburg, Germany.; Core-Facility Brain Imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Kircher+T%22">Kircher T</searchLink>; Department of Psychiatry, University of Marburg, Marburg, Germany.; Core-Facility Brain Imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Falkenberg+I%22">Falkenberg I</searchLink>; Department of Psychiatry, University of Marburg, Marburg, Germany.; Core-Facility Brain Imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Thomas-Odenthal+F%22">Thomas-Odenthal F</searchLink>; Department of Psychiatry, University of Marburg, Marburg, Germany.; Core-Facility Brain Imaging, Faculty of Medicine, University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Lambert+M%22">Lambert M</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kraft+V%22">Kraft V</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Leicht+G%22">Leicht G</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mulert+C%22">Mulert C</searchLink>; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Marburg and Giessen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Centre for Psychiatry, Justus-Liebig University Giessen, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Fallgatter+AJ%22">Fallgatter AJ</searchLink>; Tübingen Center for Mental Health, Department of Psychiatry, University of Tübingen, Tübingen, Baden-Wurttemberg, Germany.; Partner Site Tübingen, Deutsches Zentrum für Psychische Gesundheit, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Ethofer+T%22">Ethofer T</searchLink>; Tübingen Center for Mental Health, Department of Psychiatry, University of Tübingen, Tübingen, Baden-Wurttemberg, Germany.; Partner Site Tübingen, Deutsches Zentrum für Psychische Gesundheit, Tübingen, Germany.; Biomedical Magnetic Resonance, University of Tübingen, Tuebingen, Baden-Wurttemberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rau+A%22">Rau A</searchLink>; Tübingen Center for Mental Health, Department of Psychiatry, University of Tübingen, Tübingen, Baden-Wurttemberg, Germany.<br /><searchLink fieldCode="AU" term="%22Leopold+K%22">Leopold K</searchLink>; Vivantes Hospital Am Urban and Vivantes Hospital Im Friedrichshain, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bechdolf+A%22">Bechdolf A</searchLink>; Vivantes Hospital Am Urban and Vivantes Hospital Im Friedrichshain, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Andreas+R%22">Andreas R</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Matura+S%22">Matura S</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Repple+J%22">Repple J</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.; Cooperative Brain Imaging Center - CoBIC, Goethe University Frankfurt, Frankfurt, Hesse, Germany.; Institute for Translational Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.<br /><searchLink fieldCode="AU" term="%22Bermpohl+F%22">Bermpohl F</searchLink>; Charité Campus Mitte, Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Fiebig+J%22">Fiebig J</searchLink>; Charité Campus Mitte, Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Stamm+T%22">Stamm T</searchLink>; Charité Campus Mitte, Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.; Department of Clinical Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Brandenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Correll+CU%22">Correll CU</searchLink>; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.; Department of Psychiatry, Northwell Health, Zucker Hillside Hospital, New York, NY, United States.; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States.<br /><searchLink fieldCode="AU" term="%22Juckel+G%22">Juckel G</searchLink>; Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr-University, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Flasbeck+V%22">Flasbeck V</searchLink>; Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr-University, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Wiest+IC%22">Wiest IC</searchLink>; Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Kather+JN%22">Kather JN</searchLink>; Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Dannlowski+U%22">Dannlowski U</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Bielefeld University, Bielefeld, Germany.; German Center for Mental Health (DZPG), Jena Magdeburg Halle, Germany.; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Jena Magdeburg Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Mennigen+E%22">Mennigen E</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ritter+P%22">Ritter P</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Bauer+M%22">Bauer M</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Pfennig+A%22">Pfennig A</searchLink>; Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, TUD Dresden University of Technology, Dresden, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101658926%22">JMIR mental health</searchLink> [JMIR Ment Health] 2026 Jun 22; Vol. 13, pp. e84424. <i>Date of Electronic Publication: </i>2026 Jun 22.
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