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NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease.

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Title: NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease.
Authors: Nazeen S; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang X; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Morrow AR; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Strom R; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Ethier E; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Ritter D; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA., Henderson ABH; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Afroz J; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA., Cassa CS; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Stitziel NO; Cardiovascular Division, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Gupta RM; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Luk KC; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Studer L; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Khurana V; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; Harvard Stem Cell Institute, Cambridge, MA, USA. Electronic address: khuranalab_admin@bwh.harvard.edu., Sunyaev SR; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: ssunyaev@hms.harvard.edu.
Source: Cell genomics [Cell Genom] 2026 Jun 22, pp. 101284. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: MEDLINE
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  Data: NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Nazeen+S%22">Nazeen S</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Morrow+AR%22">Morrow AR</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Strom+R%22">Strom R</searchLink>; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ethier+E%22">Ethier E</searchLink>; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ritter+D%22">Ritter D</searchLink>; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Henderson+ABH%22">Henderson ABH</searchLink>; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Afroz+J%22">Afroz J</searchLink>; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cassa+CS%22">Cassa CS</searchLink>; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stitziel+NO%22">Stitziel NO</searchLink>; Cardiovascular Division, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+RM%22">Gupta RM</searchLink>; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Luk+KC%22">Luk KC</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Studer+L%22">Studer L</searchLink>; The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Khurana+V%22">Khurana V</searchLink>; American Parkinson's Disease Association Center for Advanced Research, Harvard Biomarkers Study 2.0 and MyTrial Programs, Division of Movement Disorders, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; Harvard Stem Cell Institute, Cambridge, MA, USA. Electronic address: khuranalab_admin@bwh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Sunyaev+SR%22">Sunyaev SR</searchLink>; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: ssunyaev@hms.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%229918284260106676%22">Cell genomics</searchLink> [Cell Genom] 2026 Jun 22, pp. 101284. <i>Date of Electronic Publication: </i>2026 Jun 22.
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        Value: 10.1016/j.xgen.2026.101284
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              Text: 2026 Jun 22
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