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E4BP4 safeguards brown fat mitochondria from obesity-induced fragmentation via ceramide repression.

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Title: E4BP4 safeguards brown fat mitochondria from obesity-induced fragmentation via ceramide repression.
Authors: Valdivieso-Rivera F; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.; Graduate Program in Molecular and Morphofunctional Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Furino VO; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Leher CE; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Zanesco AM; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Cruz MK; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology-Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Gan FC; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Santoro AL; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Regina-Ferreira L; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Santos GL; Department of Pathology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Gonçalves T; Center for Research in Inflammatory Diseases (CRID), Ribeirão Preto Medical School, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, Brazil., Leiria LO; Center for Research in Inflammatory Diseases (CRID), Ribeirão Preto Medical School, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, Brazil., Moraes-Vieira PM; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology-Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Castilho RF; Department of Pathology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Kajimura S; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., Mori MA; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.; Experimental Medicine Research Cluster, Universidade Estadual de Campinas, Campinas (UNICAMP), Campinas, Brazil., Velloso LA; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil., Sponton CH; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil. csponton@usp.br.; Department of Physiology, Ribeirão Preto Medical School, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, Brazil. csponton@usp.br.
Source: EMBO reports [EMBO Rep] 2026 Jun 22. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
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  Data: E4BP4 safeguards brown fat mitochondria from obesity-induced fragmentation via ceramide repression.
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  Data: <searchLink fieldCode="AU" term="%22Valdivieso-Rivera+F%22">Valdivieso-Rivera F</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.; Graduate Program in Molecular and Morphofunctional Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Furino+VO%22">Furino VO</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Leher+CE%22">Leher CE</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Zanesco+AM%22">Zanesco AM</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Cruz+MK%22">Cruz MK</searchLink>; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology-Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Gan+FC%22">Gan FC</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Santoro+AL%22">Santoro AL</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Regina-Ferreira+L%22">Regina-Ferreira L</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos+GL%22">Santos GL</searchLink>; Department of Pathology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+T%22">Gonçalves T</searchLink>; Center for Research in Inflammatory Diseases (CRID), Ribeirão Preto Medical School, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Leiria+LO%22">Leiria LO</searchLink>; Center for Research in Inflammatory Diseases (CRID), Ribeirão Preto Medical School, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Moraes-Vieira+PM%22">Moraes-Vieira PM</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology-Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Castilho+RF%22">Castilho RF</searchLink>; Department of Pathology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Kajimura+S%22">Kajimura S</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mori+MA%22">Mori MA</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.; Experimental Medicine Research Cluster, Universidade Estadual de Campinas, Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Velloso+LA%22">Velloso LA</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Sponton+CH%22">Sponton CH</searchLink>; Obesity and Comorbidities Research Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil. csponton@usp.br.; Department of Physiology, Ribeirão Preto Medical School, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, Brazil. csponton@usp.br.
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