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Improving the clinical trial landscape for patients with atypical variants of Alzheimer's disease: a call to action.

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Title: Improving the clinical trial landscape for patients with atypical variants of Alzheimer's disease: a call to action.
Authors: Corriveau-Lecavalier N; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Falgàs N; Alzheimer's Unit and Other Cognitive Disorders, Neurology Service, Hospital Clínic de Barcelona, Fundació de Recerca Clínic Barcelona -IDIBAPS, Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Putcha D; Department of Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital & Department of Neurology, Boston, Massachusetts, USA.; Center for Brain Mind Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Yong KXX; Queen Square Institute of Neurology, University College London, London, UK., Boon BDC; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands., Mohanty R; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden., Westman E; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden., Groot C; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands., Jones DT; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Grinberg LT; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.; Edward and Pearl Fein Memory and Aging Center, Weill Institute of Neuroscience, Departments of Neurology, Radiology & Biomedical Imaging, University of California, San Francisco, California, USA.; LIM-22, Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil., Rabinovici GD; Edward and Pearl Fein Memory and Aging Center, Weill Institute of Neuroscience, Departments of Neurology, Radiology & Biomedical Imaging, University of California, San Francisco, California, USA., Whitwell JL; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., Apostolova LG; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Neurology, Washington University School of Medicine in, St. Louis, Missouri, USA., Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA., Hammers DB; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Schindler SE; Knight Alzheimer Disease Research Center, St. Louis, Missouri, USA., Atonsdottir I; Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease, Department of Psychiatry & Behavioral Sciences, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA.; Division of Geriatric Medicine and Gerontology, Johns Hopkins Bayview Medical Center, Hopkins Bayview Circle, Baltimore, Maryland, USA., Rhodus EK; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Behavioral Science, University of Kentucky, Lexington, Kentucky, USA.; Center for Health Equity Transformation, University of Kentucky, Lexington, Kentucky, USA., Schott JM; Dementia Research Centre, University College London, Institute of Neurology, London, UK., Illán-Gala I; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Chukwuanugo O; Department of Community Medicine, Centre for Primary Health Care, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Guerra JJL; Department of Neurology, Washington University School of Medicine in, St. Louis, Missouri, USA., Peters R; Department of Psychology University of New South Wales, Sydney, New South Wales, Australia.; College of Public Health, University of Kentucky, Lexington, Kentucky, USA., Abner EL; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; College of Public Health, University of Kentucky, Lexington, Kentucky, USA., Abdelnour C; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Lladó A; Alzheimer's Unit and Other Cognitive Disorders, Neurology Service, Hospital Clínic de Barcelona, Fundació de Recerca Clínic Barcelona -IDIBAPS, Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain., La Joie R; Edward and Pearl Fein Memory and Aging Center, Weill Institute of Neuroscience, Departments of Neurology, Radiology & Biomedical Imaging, University of California, San Francisco, California, USA., de Souza LC; Instituto de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Grupo de Neurologia Cognitiva e do Comportamento, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Rezaii N; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital & Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA., Shir D; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Pijenburg YAL; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands., Carrillo MC; Alzheimer's Association, Chicago, Illinois, USA., Dickerson BC; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital & Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA., Aisen P; University of California San Diego, San Diego, California, USA.; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, California, USA., Ossenkoppele R; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden., Raman R; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, California, USA.; University of Southern California, Los Angeles, California, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jun; Vol. 22 (6), pp. e71521.
Publication Type: Journal Article; Review
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Neurology, Washington University School of Medicine in, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Murray+ME%22">Murray ME</searchLink>; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Hammers+DB%22">Hammers DB</searchLink>; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Schindler+SE%22">Schindler SE</searchLink>; Knight Alzheimer Disease Research Center, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Atonsdottir+I%22">Atonsdottir I</searchLink>; Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease, Department of Psychiatry & Behavioral Sciences, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA.; 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