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Combining post-mortem and neuroimaging measures of brain amyloidosis to accelerate genomic discovery.

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Title: Combining post-mortem and neuroimaging measures of brain amyloidosis to accelerate genomic discovery.
Authors: Wang TC; Vanderbilt Memory and Alzheimer's Center, Vanderbilt Health, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt Health, Nashville, TN, 37232, USA., Archer DB; Vanderbilt Memory and Alzheimer's Center, Vanderbilt Health, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt Health, Nashville, TN, 37232, USA., Ali M; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63108, USA., Wu Y; Vanderbilt Memory and Alzheimer's Center, Vanderbilt Health, Nashville, TN, 37203, USA., Mormino E; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA., Buckley RF; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Lee AJ; Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Neurology, The New York Presbyterian Hospital, New York, NY, 10032, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, 10032, USA., Saykin AJ; Department of Radiology and Imaging Sciences, Center for Neuroimaging, School of Medicine, Indiana University, Indianapolis, IN, 46202, USA.; Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, 46202, USA., De Jager PL; Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Neurology, The New York Presbyterian Hospital, New York, NY, 10032, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, 10032, USA.; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Barnes LL; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Vardarajan B; Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Neurology, The New York Presbyterian Hospital, New York, NY, 10032, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, 10032, USA.; The Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, 10032, USA., Mayeux R; Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Neurology, The New York Presbyterian Hospital, New York, NY, 10032, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, 10032, USA.; The Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, 10032, USA., Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, FL, 33136, USA., Bush WS; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA., Dirk Keene C; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA., Seshadri S; Department of Neurology, Chobanian and Avedisian School of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Sperling RA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Vemuri P; Department of Radiology, Mayo Clinic-Minnesota, Rochester, MN, 55905, USA., Ramanan VK; Department of Radiology, Mayo Clinic-Minnesota, Rochester, MN, 55905, USA., Ilyas Kamboh M; Department of Human Genetics, Epidemiology and Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Harrison TM; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA., Jagust WJ; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Laws SM; Centre for Precision Health, Edith Cowan University, Joondalup, WA, 6027, Australia., Schellenberg GD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Huentelman M; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA., Hamilton-Nelson K; John P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, FL, 33136, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, FL, 33136, USA., Goate AM; Ronald M Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Haines JL; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA., Montine TJ; Department of Pathology, Stanford University, Stanford, CA, 94305, USA., Beecham G; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA., Below JE; Vanderbilt Genetics Institute, Vanderbilt Health, Nashville, TN, 37232, USA., Cruchaga C; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63108, USA.; Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO, 63108, USA.; Hope Center for Neurologic Diseases, Washington University, St. Louis, MO, 63110, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63110, USA., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Vanderbilt Health, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt Health, Nashville, TN, 37232, USA., Dumitrescu L; Vanderbilt Memory and Alzheimer's Center, Vanderbilt Health, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt Health, Nashville, TN, 37232, USA.
Source: Brain : a journal of neurology [Brain] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
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  Data: Combining post-mortem and neuroimaging measures of brain amyloidosis to accelerate genomic discovery.
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  Data: <searchLink fieldCode="AU" term="%22Wang+TC%22">Wang TC</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt Health, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt Health, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Archer+DB%22">Archer DB</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt Health, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt Health, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Ali+M%22">Ali M</searchLink>; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63108, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt Health, Nashville, TN, 37203, USA.<br /><searchLink fieldCode="AU" term="%22Mormino+E%22">Mormino E</searchLink>; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.<br /><searchLink fieldCode="AU" term="%22Buckley+RF%22">Buckley RF</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lee+AJ%22">Lee AJ</searchLink>; Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Neurology, The New York Presbyterian Hospital, New York, NY, 10032, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Saykin+AJ%22">Saykin AJ</searchLink>; Department of Radiology and Imaging Sciences, Center for Neuroimaging, School of Medicine, Indiana University, Indianapolis, IN, 46202, USA.; Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+PL%22">De Jager PL</searchLink>; Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Neurology, The New York Presbyterian Hospital, New York, NY, 10032, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, 10032, USA.; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+JA%22">Schneider JA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.<br /><searchLink fieldCode="AU" term="%22Barnes+LL%22">Barnes LL</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.<br /><searchLink fieldCode="AU" term="%22Vardarajan+B%22">Vardarajan B</searchLink>; Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Neurology, The New York Presbyterian Hospital, New York, NY, 10032, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, 10032, USA.; The Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Mayeux+R%22">Mayeux R</searchLink>; Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Neurology, The New York Presbyterian Hospital, New York, NY, 10032, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, 10032, USA.; The Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Kunkle+BW%22">Kunkle BW</searchLink>; John P. 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