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Development of XYD113 as a potent and highly selective GSPT1 degrader for cancer therapy.

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Title: Development of XYD113 as a potent and highly selective GSPT1 degrader for cancer therapy.
Authors: Shen H; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Luo XY; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Jing XY; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.; School of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China., Jin WQ; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.; School of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China., Xu HR; Department of Chemical Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China., Hu JK; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Zhong ZX; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Zhang J; Laboratory Animal Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Liang HZ; Laboratory Animal Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Zhuang XX; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Ge HH; School of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China., Smaill JB; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, 1142, New Zealand., Xu JX; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Zhang Y; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Patterson AV; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, 1142, New Zealand. a.patterson@auckland.ac.nz., Ma JM; School of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China. jmma@ahu.edu.cn., Xu Y; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. xu_yong@gibh.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
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  Data: Development of XYD113 as a potent and highly selective GSPT1 degrader for cancer therapy.
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  Data: <searchLink fieldCode="AU" term="%22Shen+H%22">Shen H</searchLink>; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Luo+XY%22">Luo XY</searchLink>; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Jing+XY%22">Jing XY</searchLink>; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.; School of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.<br /><searchLink fieldCode="AU" term="%22Jin+WQ%22">Jin WQ</searchLink>; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.; School of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.<br /><searchLink fieldCode="AU" term="%22Xu+HR%22">Xu HR</searchLink>; Department of Chemical Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China.<br /><searchLink fieldCode="AU" term="%22Hu+JK%22">Hu JK</searchLink>; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Zhong+ZX%22">Zhong ZX</searchLink>; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Laboratory Animal Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Liang+HZ%22">Liang HZ</searchLink>; Laboratory Animal Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Zhuang+XX%22">Zhuang XX</searchLink>; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Ge+HH%22">Ge HH</searchLink>; School of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China.<br /><searchLink fieldCode="AU" term="%22Smaill+JB%22">Smaill JB</searchLink>; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, 1142, New Zealand.<br /><searchLink fieldCode="AU" term="%22Xu+JX%22">Xu JX</searchLink>; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Patterson+AV%22">Patterson AV</searchLink>; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, 1142, New Zealand. a.patterson@auckland.ac.nz.<br /><searchLink fieldCode="AU" term="%22Ma+JM%22">Ma JM</searchLink>; School of Life Sciences and Medical Engineering, Anhui University, Hefei, 230601, China. jmma@ahu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. xu_yong@gibh.ac.cn.
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        Value: 10.1038/s41401-026-01856-z
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        Text: English
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              Text: 2026 Jun 23
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