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Space radiation and microgravity as models of accelerated aging: modulation of hepatic miRNA-TGF-β networks associated with senescence and fibrosis.

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Title: Space radiation and microgravity as models of accelerated aging: modulation of hepatic miRNA-TGF-β networks associated with senescence and fibrosis.
Authors: Hayslip N; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.; USF Health Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Kim J; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Ashiqueali SA; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA., Zhu X; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA., Hussein R; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA., Alam MT; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA., Garcia DN; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, Brazil., Zanini BM; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, Brazil., Kubik A; Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA., Allen N; Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA., Blaber EA; Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.; Center for Engineering and Precision Medicine, Rensselaer-Icahn School of Medicine at Mount Sinai, New York, NY, USA., Siddiqi SS; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA., Mansoor MAM; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA., Schisler JC; McAllister Heart Institute and Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Mason CE; Department of Physiology, Biophysics and Systems Biology and the WorldQuant Initiative, Weill Cornell Medicine, New York, NY, USA.; Trivedi Institute of Space and Global Biomedicine, Pittsburgh, PA, USA., Beheshti A; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. beheshti@pitt.edu.; Center for Space Biomedicine, Trivedi Institute for Space and Global Biomedicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. beheshti@pitt.edu.; Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. beheshti@pitt.edu.; Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. beheshti@pitt.edu., Masternak MM; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA. michal.masternak@ucf.edu.; Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland. michal.masternak@ucf.edu.
Source: GeroScience [Geroscience] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Space radiation and microgravity as models of accelerated aging: modulation of hepatic miRNA-TGF-β networks associated with senescence and fibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Hayslip+N%22">Hayslip N</searchLink>; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.; USF Health Morsani College of Medicine, University of South Florida, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ashiqueali+SA%22">Ashiqueali SA</searchLink>; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Hussein+R%22">Hussein R</searchLink>; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Alam+MT%22">Alam MT</searchLink>; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Garcia+DN%22">Garcia DN</searchLink>; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Zanini+BM%22">Zanini BM</searchLink>; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Kubik+A%22">Kubik A</searchLink>; Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.<br /><searchLink fieldCode="AU" term="%22Allen+N%22">Allen N</searchLink>; Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.<br /><searchLink fieldCode="AU" term="%22Blaber+EA%22">Blaber EA</searchLink>; Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.; Center for Engineering and Precision Medicine, Rensselaer-Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Siddiqi+SS%22">Siddiqi SS</searchLink>; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Mansoor+MAM%22">Mansoor MAM</searchLink>; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Schisler+JC%22">Schisler JC</searchLink>; McAllister Heart Institute and Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Mason+CE%22">Mason CE</searchLink>; Department of Physiology, Biophysics and Systems Biology and the WorldQuant Initiative, Weill Cornell Medicine, New York, NY, USA.; Trivedi Institute of Space and Global Biomedicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Beheshti+A%22">Beheshti A</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. beheshti@pitt.edu.; Center for Space Biomedicine, Trivedi Institute for Space and Global Biomedicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. beheshti@pitt.edu.; Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. beheshti@pitt.edu.; Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. beheshti@pitt.edu.<br /><searchLink fieldCode="AU" term="%22Masternak+MM%22">Masternak MM</searchLink>; College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA. michal.masternak@ucf.edu.; Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland. michal.masternak@ucf.edu.
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