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Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes.

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Title: Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes.
Authors: Jeffrey M; Division of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Cambridge, UK., Bartholdson Scott J; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK., Mazumdar S; Division of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Cambridge, UK., White RJ; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK., Higginson E; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Maes M; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK., Forrest S; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; The School of Medicine, University of St Andrews, St Andrews, UK., Pereira-Dias J; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Parmar S; Clinical Microbiology and Public Health Laboratory, UK Health Security Agency, Cambridge, UK., Heasman-Hunt E; Clinical Microbiology and Public Health Laboratory, UK Health Security Agency, Cambridge, UK., Curran MD; Clinical Microbiology and Public Health Laboratory, UK Health Security Agency, Cambridge, UK., Polgarova P; John V Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK., Herre J; Department of Respiratory Medicine, Addenbrooke's Hospital, Cambridge, UK., Wauters E; Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.; Department of Pneumology, University Hospitals Leuven, Leuven, Belgium., Lambrechts D; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB Center for Cancer Biology, VIB, Leuven, Belgium., Van Mol P; Department of Pneumology, University Hospitals Leuven, Leuven, Belgium.; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Jacobs C; Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium., Wauters J; Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium., Davenport EE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Baker S; A*STAR Infectious Diseases Labs (A*STAR IDL), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Dougan G; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; Centre for Translational Stem Cell Biology, LKS Faculty of Medicine, Hong Kong University, Hong Kong, China., Navapurkar V; John V Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK., Conway Morris A; Division of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Cambridge, UK. ac926@cam.ac.uk.; John V Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK. ac926@cam.ac.uk.
Source: Nature communications [Nat Commun] 2026 Jun 23; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes.
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  Data: <searchLink fieldCode="AU" term="%22Jeffrey+M%22">Jeffrey M</searchLink>; Division of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bartholdson+Scott+J%22">Bartholdson Scott J</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mazumdar+S%22">Mazumdar S</searchLink>; Division of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22White+RJ%22">White RJ</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Higginson+E%22">Higginson E</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Maes+M%22">Maes M</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Forrest+S%22">Forrest S</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; The School of Medicine, University of St Andrews, St Andrews, UK.<br /><searchLink fieldCode="AU" term="%22Pereira-Dias+J%22">Pereira-Dias J</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Parmar+S%22">Parmar S</searchLink>; Clinical Microbiology and Public Health Laboratory, UK Health Security Agency, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Heasman-Hunt+E%22">Heasman-Hunt E</searchLink>; Clinical Microbiology and Public Health Laboratory, UK Health Security Agency, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Curran+MD%22">Curran MD</searchLink>; Clinical Microbiology and Public Health Laboratory, UK Health Security Agency, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Polgarova+P%22">Polgarova P</searchLink>; John V Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Herre+J%22">Herre J</searchLink>; Department of Respiratory Medicine, Addenbrooke's Hospital, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wauters+E%22">Wauters E</searchLink>; Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.; Department of Pneumology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Lambrechts+D%22">Lambrechts D</searchLink>; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB Center for Cancer Biology, VIB, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Mol+P%22">Van Mol P</searchLink>; Department of Pneumology, University Hospitals Leuven, Leuven, Belgium.; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Jacobs+C%22">Jacobs C</searchLink>; Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Wauters+J%22">Wauters J</searchLink>; Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Davenport+EE%22">Davenport EE</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Baker+S%22">Baker S</searchLink>; A*STAR Infectious Diseases Labs (A*STAR IDL), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Dougan+G%22">Dougan G</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; Centre for Translational Stem Cell Biology, LKS Faculty of Medicine, Hong Kong University, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Navapurkar+V%22">Navapurkar V</searchLink>; John V Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Conway+Morris+A%22">Conway Morris A</searchLink>; Division of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Cambridge, UK. ac926@cam.ac.uk.; John V Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK. ac926@cam.ac.uk.
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