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NG2-ITGA4 axis regulates Rho GTPases and leukemic aggressiveness in KMT2A-r B-ALL and is targetable with natalizumab.

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Title: NG2-ITGA4 axis regulates Rho GTPases and leukemic aggressiveness in KMT2A-r B-ALL and is targetable with natalizumab.
Authors: Rubio-Gayarre A; Josep Carreras Leukaemia Research Institute, Barcelona, Spain., Vinyoles M; Josep Carreras Leukemia Research Institute, Barcelona, Spain., Tejedor JR; Institute of Oncology of Asturias (IUOPA), ISPA-HUCA, Spain., Guerrero-Murillo M; Josep Carreras Leukaemia Research Institute, Barcelona, Spain., Fernandez-Fuentes N; Josep Carreras Leukemia Research Institute., Barcelona, Spain., Caracuel-Peramos R; GENYO. Center for Genomics and Oncological Research: Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain., Plaza-Calonge MC; GENYO. Center for Genomics and Oncological Research: Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain., Martinez-Moreno A; Josep Carreras Leukaemia Research Institute, Department of Biomedicine, School of Medicine,, Barcelona, Spain., Roca-Ho H; IJC, Barcelona, Spain., Petazzi P; Josep Carreras Leukaemia Research Institute, Barcelona, Spain., Pañella-Alférez A; GENYO. Center for Genomics and Oncological Research: Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain., Meseguer-Giron A; Josep Carreras Leukemia Research Institute, Barcelona, Spain., Vrenken KS; Princess Maxima Center, Utrecht, Netherlands., Fraga MF; CINN-ISPA, Oviedo, Spain., Leoz Allegretti P; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Palacio-Garcia C; 4. Servei d'Hematologia, Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, Barcelona, Spain., Velasco P; Hospital Vall d'Hebrón. Universitat Autonoma de Barcelona, Barcelona, Spain., Fuster JL Sr; Hospital Clínico Universitario Virgen de la Arrixaca. Instituto Murciano de Investigación Biosanitaria (IMIB), Pilar de la Horadada. Alicante, Spain., Stam RW; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands., Rodríguez-Manzaneque JC; GENYO. Center for Genomics and Oncological Research: Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain., Bustelo XR; Centro de Investigacion del Cancer, Salamanca, Spain., Robles-Valero J; Centro de Investigacion del Cancer, Salamanca, Spain., Menendez P; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Spain., Bueno C; Josep Carreras Leukemia Research Institute, Barcelona, Spain., Lopez-Millan B; Josep Carreras Leukemia Research Institute, Barcelona, Spain.
Source: Blood [Blood] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NG2-ITGA4 axis regulates Rho GTPases and leukemic aggressiveness in KMT2A-r B-ALL and is targetable with natalizumab.
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  Data: <searchLink fieldCode="AU" term="%22Rubio-Gayarre+A%22">Rubio-Gayarre A</searchLink>; Josep Carreras Leukaemia Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vinyoles+M%22">Vinyoles M</searchLink>; Josep Carreras Leukemia Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Tejedor+JR%22">Tejedor JR</searchLink>; Institute of Oncology of Asturias (IUOPA), ISPA-HUCA, Spain.<br /><searchLink fieldCode="AU" term="%22Guerrero-Murillo+M%22">Guerrero-Murillo M</searchLink>; Josep Carreras Leukaemia Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez-Fuentes+N%22">Fernandez-Fuentes N</searchLink>; Josep Carreras Leukemia Research Institute., Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Caracuel-Peramos+R%22">Caracuel-Peramos R</searchLink>; GENYO. Center for Genomics and Oncological Research: Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Plaza-Calonge+MC%22">Plaza-Calonge MC</searchLink>; GENYO. Center for Genomics and Oncological Research: Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Moreno+A%22">Martinez-Moreno A</searchLink>; Josep Carreras Leukaemia Research Institute, Department of Biomedicine, School of Medicine,, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Roca-Ho+H%22">Roca-Ho H</searchLink>; IJC, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Petazzi+P%22">Petazzi P</searchLink>; Josep Carreras Leukaemia Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pañella-Alférez+A%22">Pañella-Alférez A</searchLink>; GENYO. Center for Genomics and Oncological Research: Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Meseguer-Giron+A%22">Meseguer-Giron A</searchLink>; Josep Carreras Leukemia Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vrenken+KS%22">Vrenken KS</searchLink>; Princess Maxima Center, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Fraga+MF%22">Fraga MF</searchLink>; CINN-ISPA, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Leoz+Allegretti+P%22">Leoz Allegretti P</searchLink>; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Palacio-Garcia+C%22">Palacio-Garcia C</searchLink>; 4. Servei d'Hematologia, Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Velasco+P%22">Velasco P</searchLink>; Hospital Vall d'Hebrón. Universitat Autonoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fuster+JL+Sr%22">Fuster JL Sr</searchLink>; Hospital Clínico Universitario Virgen de la Arrixaca. Instituto Murciano de Investigación Biosanitaria (IMIB), Pilar de la Horadada. Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Stam+RW%22">Stam RW</searchLink>; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Manzaneque+JC%22">Rodríguez-Manzaneque JC</searchLink>; GENYO. Center for Genomics and Oncological Research: Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Bustelo+XR%22">Bustelo XR</searchLink>; Centro de Investigacion del Cancer, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Robles-Valero+J%22">Robles-Valero J</searchLink>; Centro de Investigacion del Cancer, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Menendez+P%22">Menendez P</searchLink>; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Spain.<br /><searchLink fieldCode="AU" term="%22Bueno+C%22">Bueno C</searchLink>; Josep Carreras Leukemia Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lopez-Millan+B%22">Lopez-Millan B</searchLink>; Josep Carreras Leukemia Research Institute, Barcelona, Spain.
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        Value: 10.1182/blood.2025031693
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        Text: English
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