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Thiazolidinedione-triazole hybrids: design, synthesis, and biological evaluation as dual inhibitors of α-amylase and aldose reductase with antioxidant activity for antidiabetic therapy.

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Title: Thiazolidinedione-triazole hybrids: design, synthesis, and biological evaluation as dual inhibitors of α-amylase and aldose reductase with antioxidant activity for antidiabetic therapy.
Authors: Nasr EE; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., Elnagar MR; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, 11823, Egypt.; Department of Pharmacology, College of Pharmacy, The Islamic University, Najaf, 54001, Iraq., El-Sayed NNE; Egyptian Drug Authority, 51 Wezaret El-Zerra St., Al agouzah, Giza, 35521, Egypt., Serag MI; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., Elbadawi MM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, P.O. Box 33516, Kafrelsheikh, Egypt., El-Azab AS; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia., Brogi S; Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy., Ghabbour HA; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia., Hamdi A; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. abdelrahmanhamdi2012@yahoo.com., Abdel-Aziz AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Source: Molecular diversity [Mol Divers] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE
Database: MEDLINE Ultimate
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              Text: 2026 Jun 25
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