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Response to the Letter to the Editor Entitled "A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics".

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Title: Response to the Letter to the Editor Entitled "A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics".
Authors: Sandholm N; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland., Cole JB; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, Colorado, USA., Nair V; Department of Medicine-Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA., Brennan E; Diabetes Complications Research Centre, School of Medicine and Conway Institute, University College Dublin, Dublin, Ireland., Giardini E; Diabetes Complications Research Centre, School of Medicine and Conway Institute, University College Dublin, Dublin, Ireland., Haukka JK; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland., Ha E; Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Institute of Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Syreeni A; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland., Dahlström EH; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland., Salem RM; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA., Fermin D; Department of Pediatrics-Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA., Mercader J; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Section, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Mass General Brigham, Boston, Massachusetts, USA., Smyth L; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Hill C; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Mychaleckyj J; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., McGurnaghan S; Western General Hospital, The Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Miller RG; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Costacou T; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Snell-Bergeon J; Barbara Davis Center for Diabetes, University of Colorado Denver, Aurora, Colorado, USA., Paterson AD; Genetics & Genome Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada., Verkauskiene R; Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Sokolovska J; Faculty of Medicine and Life Sciences, University of Latvia, Riga, Latvia., Panduru NM; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; 2nd Clinical Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.; Integrated Metabolic Investigation (IMI)-Center of Diabetes, Nutrition and Metabolism, Bucharest, Romania., Zerbini G; Complications of Diabetes Unit, Division of Immunology, Transplantation and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milano, Italy., Brismar K; Department of Molecular Medicine and Surgery, Rolf Luft Center for Diabetes Research and Endocrinology, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology, Diabetes and Metabolism, Karolinska University Hospital, Stockholm, Sweden., Krolewski AS; Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Harjutsalo V; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland., Rossing P; Steno Diabetes Center Copenhagen, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Hadjadj S; INSERM CIC (Centre d'Investigation Clinique) 1402 and U 1082 (IRTOMIT), Poitiers, France.; Department of Endocrinology, L'institut du thorax, INSERM, Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire de Nantes, Nantes, France., McKay G; Centre for Public Health, Queen's University of Belfast, Belfast, UK., McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Maxwell AP; Centre for Public Health, Queen's University of Belfast, Belfast, UK.; Regional Nephrology Unit, Belfast City Hospital, Belfast, UK., Susztak K; Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Institute of Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Penn-CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Godson C; Diabetes Complications Research Centre, School of Medicine and Conway Institute, University College Dublin, Dublin, Ireland., Kretzler M; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Hirschhorn JN; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pediatrics and Genetics, Harvard Medical School, Boston, Massachusetts, USA., Florez JC; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Section, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Mass General Brigham, Boston, Massachusetts, USA., Groop PH; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.; Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Corporate Authors: GENIE Consortium
Source: Kidney international reports [Kidney Int Rep] 2026 Apr 29; Vol. 11 (7), pp. 106572. Date of Electronic Publication: 2026 Apr 29 (Print Publication: 2026).
Publication Type: Letter
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101684752 Publication Model: eCollection Cited Medium: Internet ISSN: 2468-0249 (Electronic) Linking ISSN: 24680249 NLM ISO Abbreviation: Kidney Int Rep Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Editorial & Opinion
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  Data: Response to the Letter to the Editor Entitled "A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics".
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  Data: <searchLink fieldCode="AU" term="%22Sandholm+N%22">Sandholm N</searchLink>; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Cole+JB%22">Cole JB</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Nair+V%22">Nair V</searchLink>; Department of Medicine-Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Brennan+E%22">Brennan E</searchLink>; Diabetes Complications Research Centre, School of Medicine and Conway Institute, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Giardini+E%22">Giardini E</searchLink>; Diabetes Complications Research Centre, School of Medicine and Conway Institute, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Haukka+JK%22">Haukka JK</searchLink>; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Ha+E%22">Ha E</searchLink>; Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Institute of Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Syreeni+A%22">Syreeni A</searchLink>; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Dahlström+EH%22">Dahlström EH</searchLink>; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Salem+RM%22">Salem RM</searchLink>; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Fermin+D%22">Fermin D</searchLink>; Department of Pediatrics-Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Mercader+J%22">Mercader J</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Section, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Mass General Brigham, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Smyth+L%22">Smyth L</searchLink>; Centre for Public Health, Queen's University of Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Hill+C%22">Hill C</searchLink>; Centre for Public Health, Queen's University of Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Mychaleckyj+J%22">Mychaleckyj J</searchLink>; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22McGurnaghan+S%22">McGurnaghan S</searchLink>; Western General Hospital, The Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Miller+RG%22">Miller RG</searchLink>; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Costacou+T%22">Costacou T</searchLink>; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Snell-Bergeon+J%22">Snell-Bergeon J</searchLink>; Barbara Davis Center for Diabetes, University of Colorado Denver, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Paterson+AD%22">Paterson AD</searchLink>; Genetics & Genome Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Verkauskiene+R%22">Verkauskiene R</searchLink>; Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.<br /><searchLink fieldCode="AU" term="%22Sokolovska+J%22">Sokolovska J</searchLink>; Faculty of Medicine and Life Sciences, University of Latvia, Riga, Latvia.<br /><searchLink fieldCode="AU" term="%22Panduru+NM%22">Panduru NM</searchLink>; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; 2nd Clinical Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.; Integrated Metabolic Investigation (IMI)-Center of Diabetes, Nutrition and Metabolism, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Zerbini+G%22">Zerbini G</searchLink>; Complications of Diabetes Unit, Division of Immunology, Transplantation and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Brismar+K%22">Brismar K</searchLink>; Department of Molecular Medicine and Surgery, Rolf Luft Center for Diabetes Research and Endocrinology, Karolinska Institutet, Stockholm, Sweden.; Department of Endocrinology, Diabetes and Metabolism, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Krolewski+AS%22">Krolewski AS</searchLink>; Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Harjutsalo+V%22">Harjutsalo V</searchLink>; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Rossing+P%22">Rossing P</searchLink>; Steno Diabetes Center Copenhagen, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hadjadj+S%22">Hadjadj S</searchLink>; INSERM CIC (Centre d'Investigation Clinique) 1402 and U 1082 (IRTOMIT), Poitiers, France.; Department of Endocrinology, L'institut du thorax, INSERM, Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire de Nantes, Nantes, France.<br /><searchLink fieldCode="AU" term="%22McKay+G%22">McKay G</searchLink>; Centre for Public Health, Queen's University of Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22McKnight+AJ%22">McKnight AJ</searchLink>; Centre for Public Health, Queen's University of Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Maxwell+AP%22">Maxwell AP</searchLink>; Centre for Public Health, Queen's University of Belfast, Belfast, UK.; Regional Nephrology Unit, Belfast City Hospital, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Susztak+K%22">Susztak K</searchLink>; Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Institute of Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Penn-CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Godson+C%22">Godson C</searchLink>; Diabetes Complications Research Centre, School of Medicine and Conway Institute, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Kretzler+M%22">Kretzler M</searchLink>; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Hirschhorn+JN%22">Hirschhorn JN</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pediatrics and Genetics, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Florez+JC%22">Florez JC</searchLink>; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Diabetes Section, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Mass General Brigham, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Groop+PH%22">Groop PH</searchLink>; Folkhälsan Research Center, Helsinki, Finland.; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.; Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
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