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Collagen-producing eye cell atlas reveals distinct fibroblast fates in early injury vs. fibrotic subretinal disease.

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Title: Collagen-producing eye cell atlas reveals distinct fibroblast fates in early injury vs. fibrotic subretinal disease.
Authors: Ozaki E; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland., Aktas S; Pharma Research and Early Development, Roche Innovation Center Zurich, Roche Glycart AG., Schlieren 8952, Switzerland., Mulfaul K; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242-1109.; Institute for Vision Research, University of Iowa, Iowa City, IA 52242-1091., Brennan K; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland., Roubeix C; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland., Palko S; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland., Robb K; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.; Progressive Vision Research, Dublin 18, Ireland.; The Royal Victoria Eye and Ear Hospital, Dublin 2, Ireland., Ou Yang TH; Roche Pharma Research and Early Development, Data and Analytics, Roche Translational & Clinical Research Center, F. Hoffmann-La Roche Ltd., Little Falls, NJ 07424., Schanne-Klein MC; Laboratoire d'Optique et Biosciences, Ecole Polytechnique, CNRS, INSERM, Institut Polytechnique de Paris, Palaiseau 91120, France., Toidze A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4056, Switzerland., Watson A; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland., Cahill M; Progressive Vision Research, Dublin 18, Ireland.; The Royal Victoria Eye and Ear Hospital, Dublin 2, Ireland., Westenskow PD; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland., Feenstra D; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland., Doyle SL; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 30; Vol. 123 (26), pp. e2519056123. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Collagen-producing eye cell atlas reveals distinct fibroblast fates in early injury vs. fibrotic subretinal disease.
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  Data: <searchLink fieldCode="AU" term="%22Ozaki+E%22">Ozaki E</searchLink>; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Aktas+S%22">Aktas S</searchLink>; Pharma Research and Early Development, Roche Innovation Center Zurich, Roche Glycart AG., Schlieren 8952, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mulfaul+K%22">Mulfaul K</searchLink>; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242-1109.; Institute for Vision Research, University of Iowa, Iowa City, IA 52242-1091.<br /><searchLink fieldCode="AU" term="%22Brennan+K%22">Brennan K</searchLink>; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Roubeix+C%22">Roubeix C</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Palko+S%22">Palko S</searchLink>; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Robb+K%22">Robb K</searchLink>; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.; Progressive Vision Research, Dublin 18, Ireland.; The Royal Victoria Eye and Ear Hospital, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Ou+Yang+TH%22">Ou Yang TH</searchLink>; Roche Pharma Research and Early Development, Data and Analytics, Roche Translational & Clinical Research Center, F. Hoffmann-La Roche Ltd., Little Falls, NJ 07424.<br /><searchLink fieldCode="AU" term="%22Schanne-Klein+MC%22">Schanne-Klein MC</searchLink>; Laboratoire d'Optique et Biosciences, Ecole Polytechnique, CNRS, INSERM, Institut Polytechnique de Paris, Palaiseau 91120, France.<br /><searchLink fieldCode="AU" term="%22Toidze+A%22">Toidze A</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Watson+A%22">Watson A</searchLink>; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Cahill+M%22">Cahill M</searchLink>; Progressive Vision Research, Dublin 18, Ireland.; The Royal Victoria Eye and Ear Hospital, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Westenskow+PD%22">Westenskow PD</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Feenstra+D%22">Feenstra D</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Doyle+SL%22">Doyle SL</searchLink>; Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.
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