View in EDS

Dual-target mu opioid-dopamine D3 receptor (MOR-D3R) ligands based on etonitazene: New leads for transforming "nitazenes" into novel analgesics.

Saved in:
Bibliographic Details
Title: Dual-target mu opioid-dopamine D3 receptor (MOR-D3R) ligands based on etonitazene: New leads for transforming "nitazenes" into novel analgesics.
Authors: Jahan K; Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA., Glatfelter G; Designer Drug Research Unit, NIDA-IRP, Baltimore, MD, USA., Sanchez J; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham and Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Nottingham, Midlands, UK., Maitland AD; Designer Drug Research Unit, NIDA-IRP, Baltimore, MD, USA., Bonifazi A; Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA; Department of Pharmacology and Toxicology, Center for Addiction Sciences and Therapeutics, University of Texas Medical Branch, Galveston, TX, USA., Saab E; Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA., Keegan BM; Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA., Rais R; Johns Hopkins Drug Discovery Program, Johns Hopkins School of Medicine, Baltimore, MD, USA., Bi GH; Addiction Biology Unit, Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA., Gomez JL; Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, NIDA-IRP, Baltimore, MD, USA., Michaelides M; Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, NIDA-IRP, Baltimore, MD, USA., Xi ZX; Addiction Biology Unit, Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA., Lane JR; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham and Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Nottingham, Midlands, UK., Canals M; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham and Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Nottingham, Midlands, UK., Baumann MH; Designer Drug Research Unit, NIDA-IRP, Baltimore, MD, USA., Newman AH; Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA. Electronic address: anewman@intra.nida.nih.gov.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Jun 22; Vol. 317, pp. 119079. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42361479
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Dual-target mu opioid-dopamine D<subscript>3</subscript> receptor (MOR-D<subscript>3</subscript>R) ligands based on etonitazene: New leads for transforming "nitazenes" into novel analgesics.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Jahan+K%22">Jahan K</searchLink>; Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Glatfelter+G%22">Glatfelter G</searchLink>; Designer Drug Research Unit, NIDA-IRP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sanchez+J%22">Sanchez J</searchLink>; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham and Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Nottingham, Midlands, UK.<br /><searchLink fieldCode="AU" term="%22Maitland+AD%22">Maitland AD</searchLink>; Designer Drug Research Unit, NIDA-IRP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bonifazi+A%22">Bonifazi A</searchLink>; Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA; Department of Pharmacology and Toxicology, Center for Addiction Sciences and Therapeutics, University of Texas Medical Branch, Galveston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Saab+E%22">Saab E</searchLink>; Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Keegan+BM%22">Keegan BM</searchLink>; Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rais+R%22">Rais R</searchLink>; Johns Hopkins Drug Discovery Program, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bi+GH%22">Bi GH</searchLink>; Addiction Biology Unit, Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gomez+JL%22">Gomez JL</searchLink>; Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, NIDA-IRP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Michaelides+M%22">Michaelides M</searchLink>; Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, NIDA-IRP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Xi+ZX%22">Xi ZX</searchLink>; Addiction Biology Unit, Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lane+JR%22">Lane JR</searchLink>; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham and Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Nottingham, Midlands, UK.<br /><searchLink fieldCode="AU" term="%22Canals+M%22">Canals M</searchLink>; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham and Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Nottingham, Midlands, UK.<br /><searchLink fieldCode="AU" term="%22Baumann+MH%22">Baumann MH</searchLink>; Designer Drug Research Unit, NIDA-IRP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Newman+AH%22">Newman AH</searchLink>; Molecular Targets and Medications Discovery Branch, NIDA-IRP, Baltimore, MD, USA. Electronic address: anewman@intra.nida.nih.gov.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Jun 22; Vol. 317, pp. 119079. <i>Date of Electronic Publication: </i>2026 Jun 22.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42361479
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.ejmech.2026.119079
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 119079
    Titles:
      – TitleFull: Dual-target mu opioid-dopamine D3 receptor (MOR-D3R) ligands based on etonitazene: New leads for transforming "nitazenes" into novel analgesics.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jahan K
      – PersonEntity:
          Name:
            NameFull: Glatfelter G
      – PersonEntity:
          Name:
            NameFull: Sanchez J
      – PersonEntity:
          Name:
            NameFull: Maitland AD
      – PersonEntity:
          Name:
            NameFull: Bonifazi A
      – PersonEntity:
          Name:
            NameFull: Saab E
      – PersonEntity:
          Name:
            NameFull: Keegan BM
      – PersonEntity:
          Name:
            NameFull: Rais R
      – PersonEntity:
          Name:
            NameFull: Bi GH
      – PersonEntity:
          Name:
            NameFull: Gomez JL
      – PersonEntity:
          Name:
            NameFull: Michaelides M
      – PersonEntity:
          Name:
            NameFull: Xi ZX
      – PersonEntity:
          Name:
            NameFull: Lane JR
      – PersonEntity:
          Name:
            NameFull: Canals M
      – PersonEntity:
          Name:
            NameFull: Baumann MH
      – PersonEntity:
          Name:
            NameFull: Newman AH
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 22
              M: 06
              Text: 2026 Jun 22
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1768-3254
          Numbering:
            – Type: volume
              Value: 317
          Titles:
            – TitleFull: European journal of medicinal chemistry
              Type: main
ResultId 1