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Small interfering RNA-mediated silencing of mutant NPM1 suppresses acute myeloid leukemia via reversing KAT7 and p300-mediated histone acetylation.

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Title: Small interfering RNA-mediated silencing of mutant NPM1 suppresses acute myeloid leukemia via reversing KAT7 and p300-mediated histone acetylation.
Authors: Hou Y; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Xing Y; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Chen C; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Su D; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Zhou Z; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Ye Y; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Lai Z; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Peng Z; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Cai H; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Sun M; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Liu Y; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Yang B; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Huang H; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Li Z; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Li J; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Li J; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Gao H; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Li J; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Zhao H; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Shi Y; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Chen Q; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China., Long J; Department of Hematology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China., Hu J; Shanghai Institute of Hematology Blood & Marrow Transplantation Center, Department of Hematology, Collaborative Innovation Center of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhou D; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China. dwzhou@xmu.edu.cn., Chen L; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China. chenlanfen@xmu.edu.cn.
Source: Leukemia [Leukemia] 2026 Jun 26. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Small interfering RNA-mediated silencing of mutant NPM1 suppresses acute myeloid leukemia via reversing KAT7 and p300-mediated histone acetylation.
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State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Ye+Y%22">Ye Y</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Lai+Z%22">Lai Z</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Peng+Z%22">Peng Z</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Cai+H%22">Cai H</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Sun+M%22">Sun M</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Long+J%22">Long J</searchLink>; Department of Hematology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Shanghai Institute of Hematology Blood & Marrow Transplantation Center, Department of Hematology, Collaborative Innovation Center of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhou+D%22">Zhou D</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China. dwzhou@xmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiang'an Hospital, Xiang An Biomedicine Laboratory, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China. chenlanfen@xmu.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%2C+Specialist+Journals%22">Nature Publishing Group, Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8704895 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5551 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208876924%22">08876924 </searchLink><i>NLM ISO Abbreviation: </i>Leukemia <i>Subsets: </i>MEDLINE
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