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The relevance of phenotypic definition in treatment resistant forms of major depressive disorder: a narrative review.

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Title: The relevance of phenotypic definition in treatment resistant forms of major depressive disorder: a narrative review.
Authors: Paribello P; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.; Unit of Clinical Psychiatry, Department of Specialistic Medicine, University Hospital Agency of Cagliari, Cagliari, Italy., Isayeva U; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy., Lazzardi S; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy., Pinna M; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy., Contu M; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy., Meloni A; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Pisanu C; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Squassina A; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Baune BT; Department of Psychiatry, University Hospital Muenster, Münster, Germany.; Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.; The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia., Manchia M; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.; Unit of Clinical Psychiatry, Department of Specialistic Medicine, University Hospital Agency of Cagliari, Cagliari, Italy.; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Jun 12; Vol. 17, pp. 1819237. Date of Electronic Publication: 2026 Jun 12 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Paribello+P%22">Paribello P</searchLink>; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.; Unit of Clinical Psychiatry, Department of Specialistic Medicine, University Hospital Agency of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Isayeva+U%22">Isayeva U</searchLink>; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Lazzardi+S%22">Lazzardi S</searchLink>; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Pinna+M%22">Pinna M</searchLink>; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Contu+M%22">Contu M</searchLink>; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Meloni+A%22">Meloni A</searchLink>; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Pisanu+C%22">Pisanu C</searchLink>; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Squassina+A%22">Squassina A</searchLink>; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Baune+BT%22">Baune BT</searchLink>; Department of Psychiatry, University Hospital Muenster, Münster, Germany.; Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.; The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Manchia+M%22">Manchia M</searchLink>; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.; Unit of Clinical Psychiatry, Department of Specialistic Medicine, University Hospital Agency of Cagliari, Cagliari, Italy.; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2026 Jun 12; Vol. 17, pp. 1819237. <i>Date of Electronic Publication: </i>2026 Jun 12 (<i>Print Publication: </i>2026).
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