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A single-cell atlas of ulcerative colitis reveals neutrophil-stromal circuits linked to biologic therapy resistance.

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Title: A single-cell atlas of ulcerative colitis reveals neutrophil-stromal circuits linked to biologic therapy resistance.
Authors: Eshghi ST; Computational Sciences, Research and Early Development, Genentech Inc., South San Francisco, CA, United States., Gubatan JM; Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, CA, United States., Mazrooei P; Computational Sciences, Research and Early Development, Genentech Inc., South San Francisco, CA, United States., Quintanilla L; Computational Sciences, Research and Early Development, Genentech Inc., South San Francisco, CA, United States., Nguyen A; Translational Medicine, Research and Early Development, Genentech Inc, South San Francisco, CA, United States., Au-Yeung A; Translational Medicine, Research and Early Development, Genentech Inc, South San Francisco, CA, United States., Holman DR; Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, CA, United States., Takahashi C; Translational Medicine, Research and Early Development, Genentech Inc, South San Francisco, CA, United States., Schiffman C; Product Development, Data Sciences, Genentech Inc., South San Francisco, CA, United States., O'Gorman WE; Translational Medicine, Research and Early Development, Genentech Inc, South San Francisco, CA, United States., Keir ME; Immunology Discovery, Research and Early Development, Genentech Inc, South San Francisco, CA, United States., Ramanujan S; Preclinical & Translational Pharmacokinetics and Pharmacodynamics (PKPD), Genentech Inc., South San Francisco, CA, United States., Rogalla S; Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, CA, United States., Hackney JA; Computational Sciences, Research and Early Development, Genentech Inc., South San Francisco, CA, United States., McBride JM; Translational Medicine, Research and Early Development, Genentech Inc, South San Francisco, CA, United States.
Source: Frontiers in immunology [Front Immunol] 2026 Jun 11; Vol. 17, pp. 1705328. Date of Electronic Publication: 2026 Jun 11 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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