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The impact of smoking and obesity on secukinumab effectiveness in psoriatic arthritis: real-world evidence from 1202 European patients.

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Title: The impact of smoking and obesity on secukinumab effectiveness in psoriatic arthritis: real-world evidence from 1202 European patients.
Authors: Ahmadzay ZF; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Georgiadis S; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark., Østergaard M; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Glintborg B; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark., Pons M; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark., Heberg J; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark., Møller-Bisgaard S; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Reumaklinik Roskilde, Rheumatology Specialist Practice, Roskilde, Denmark., Christiansen SN; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark., Rasmussen SH; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark., Loft AG; Department of Rheumatology and DANBIO, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Castrejon I; Department of Rheumatology, Hospital General, Universitario Gregorio Marañón, Madrid, Spain.; Faculty of Medicine, Complutense University of Madrid, Madrid, Spain., Otero-Varela L; Research Unit, Spanish Society of Rheumatology, Madrid, Spain., Závada J; Institute of Rheumatology, Prague, Czech Republic.; Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic., Pavelka K; Institute of Rheumatology, Prague, Czech Republic.; Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic., Rutanen J; Centre for Rheumatic Disease, Tampere University Hospital, Tampere, Finland., Kuusalo L; Department of Rheumatology, Division of Medicine, Turku University Hospital, Turku, Finland.; Department of Internal Medicine, University of Turku, Turku, Finland., Möller B; Department Rheumatology and Immunology, Inselspital-University Hospital Bern, Bern, Switzerland., Nissen MJ; Department of Rheumatology, Geneva University Hospital, Geneva, Switzerland., Rotar Z; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Prikmajer KP; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Bernardes M; Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal.; Rheumatology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal., Gudbjornsson B; Centre for Rheumatology Research, Landspitali University Hospital, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Grondal G; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department for Rheumatology, Landspitali University Hospital, Reykjavik, Iceland., van der Horst-Bruinsma I; Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands., Laas K; Department of Rheumatology, East-Tallinn Central Hospital, Tallinn, Estonia., Michelsen B; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.; Research Unit, Sørlandet Hospital, Kristiansand, Norway., Codreanu C; Center for Rheumatic Diseases, University of Medicine and Pharmacy, Bucharest, Romania., Giuseppe DD; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Kenar-Artın G; Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul School of Medicine, Izmir, Turkey., Hetland ML; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Midtbøll Ørnbjerg L; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.
Source: EULAR rheumatology open [EULAR Rheumatol Open] 2026 Feb 16; Vol. 2 (1), pp. 234-244. Date of Electronic Publication: 2026 Feb 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9919228057406676 Publication Model: eCollection Cited Medium: Internet ISSN: 3050-7081 (Electronic) Linking ISSN: 30507081 NLM ISO Abbreviation: EULAR Rheumatol Open Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The impact of smoking and obesity on secukinumab effectiveness in psoriatic arthritis: real-world evidence from 1202 European patients.
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  Data: <searchLink fieldCode="AU" term="%22Ahmadzay+ZF%22">Ahmadzay ZF</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Georgiadis+S%22">Georgiadis S</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.<br /><searchLink fieldCode="AU" term="%22Østergaard+M%22">Østergaard M</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Glintborg+B%22">Glintborg B</searchLink>; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.<br /><searchLink fieldCode="AU" term="%22Pons+M%22">Pons M</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.<br /><searchLink fieldCode="AU" term="%22Heberg+J%22">Heberg J</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.<br /><searchLink fieldCode="AU" term="%22Møller-Bisgaard+S%22">Møller-Bisgaard S</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Reumaklinik Roskilde, Rheumatology Specialist Practice, Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Christiansen+SN%22">Christiansen SN</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.<br /><searchLink fieldCode="AU" term="%22Rasmussen+SH%22">Rasmussen SH</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.<br /><searchLink fieldCode="AU" term="%22Loft+AG%22">Loft AG</searchLink>; Department of Rheumatology and DANBIO, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Castrejon+I%22">Castrejon I</searchLink>; Department of Rheumatology, Hospital General, Universitario Gregorio Marañón, Madrid, Spain.; Faculty of Medicine, Complutense University of Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Otero-Varela+L%22">Otero-Varela L</searchLink>; Research Unit, Spanish Society of Rheumatology, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Závada+J%22">Závada J</searchLink>; Institute of Rheumatology, Prague, Czech Republic.; Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Pavelka+K%22">Pavelka K</searchLink>; Institute of Rheumatology, Prague, Czech Republic.; Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Rutanen+J%22">Rutanen J</searchLink>; Centre for Rheumatic Disease, Tampere University Hospital, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Kuusalo+L%22">Kuusalo L</searchLink>; Department of Rheumatology, Division of Medicine, Turku University Hospital, Turku, Finland.; Department of Internal Medicine, University of Turku, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Möller+B%22">Möller B</searchLink>; Department Rheumatology and Immunology, Inselspital-University Hospital Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Nissen+MJ%22">Nissen MJ</searchLink>; Department of Rheumatology, Geneva University Hospital, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rotar+Z%22">Rotar Z</searchLink>; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Prikmajer+KP%22">Prikmajer KP</searchLink>; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Bernardes+M%22">Bernardes M</searchLink>; Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal.; Rheumatology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Gudbjornsson+B%22">Gudbjornsson B</searchLink>; Centre for Rheumatology Research, Landspitali University Hospital, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Grondal+G%22">Grondal G</searchLink>; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department for Rheumatology, Landspitali University Hospital, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22van+der+Horst-Bruinsma+I%22">van der Horst-Bruinsma I</searchLink>; Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Laas+K%22">Laas K</searchLink>; Department of Rheumatology, East-Tallinn Central Hospital, Tallinn, Estonia.<br /><searchLink fieldCode="AU" term="%22Michelsen+B%22">Michelsen B</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.; Research Unit, Sørlandet Hospital, Kristiansand, Norway.<br /><searchLink fieldCode="AU" term="%22Codreanu+C%22">Codreanu C</searchLink>; Center for Rheumatic Diseases, University of Medicine and Pharmacy, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Giuseppe+DD%22">Giuseppe DD</searchLink>; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kenar-Artın+G%22">Kenar-Artın G</searchLink>; Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul School of Medicine, Izmir, Turkey.<br /><searchLink fieldCode="AU" term="%22Hetland+ML%22">Hetland ML</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Midtbøll+Ørnbjerg+L%22">Midtbøll Ørnbjerg L</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.
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