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TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis.

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Title: TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis.
Authors: Xiao LX; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China., Huang YL; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China., Liao CH; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China., Xie HP; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China., Hu H; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China., Chen DM; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China., Wang JL; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China., Gu L; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China., Gu YR; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China., Xiao J; Department of Medical Oncology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 106 Zhongshan Er Rd, Guangzhou, 510100, China. xiaojian@gdph.org.cn., Lian YF; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China. lianyf6@mail.sysu.edu.cn., Li SS; Department of Medical Oncology, The Sixth Affiliated Hospital of Sun Yat-Sen University, 26 Yuan Cun Er Heng Rd, Guangzhou, 510655, China. lishsh38@mail.sysu.edu.cn.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Jun 29. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis.
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  Data: <searchLink fieldCode="AU" term="%22Xiao+LX%22">Xiao LX</searchLink>; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Huang+YL%22">Huang YL</searchLink>; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Liao+CH%22">Liao CH</searchLink>; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Xie+HP%22">Xie HP</searchLink>; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Chen+DM%22">Chen DM</searchLink>; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Wang+JL%22">Wang JL</searchLink>; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Gu+L%22">Gu L</searchLink>; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Gu+YR%22">Gu YR</searchLink>; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China.; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Xiao+J%22">Xiao J</searchLink>; Department of Medical Oncology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 106 Zhongshan Er Rd, Guangzhou, 510100, China. xiaojian@gdph.org.cn.<br /><searchLink fieldCode="AU" term="%22Lian+YF%22">Lian YF</searchLink>; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou, 510630, China. lianyf6@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+SS%22">Li SS</searchLink>; Department of Medical Oncology, The Sixth Affiliated Hospital of Sun Yat-Sen University, 26 Yuan Cun Er Heng Rd, Guangzhou, 510655, China. lishsh38@mail.sysu.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00018-026-06315-w
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        Text: English
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      – TitleFull: TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis.
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          Dates:
            – D: 29
              M: 06
              Text: 2026 Jun 29
              Type: published
              Y: 2026
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