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Informing Sampling Design for Lung Distribution Studies Using a Pulmonary Population Minimal PBPK Model.

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Title: Informing Sampling Design for Lung Distribution Studies Using a Pulmonary Population Minimal PBPK Model.
Authors: Wen H; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Sadiq MW; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Fridén M; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Global Product Development, AstraZeneca, Gothenburg, Sweden., Hohlfeld JM; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.; German Center for Lung Research (DZL-BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Disease, Hannover Medical School, Hannover, Germany., Friberg LE; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Svensson EM; Department of Pharmacy, Uppsala University, Uppsala, Sweden. elin.svensson@uu.se.; Department of Pharmacy, Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands. elin.svensson@uu.se.
Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2026 Jun 29. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wen+H%22">Wen H</searchLink>; Department of Pharmacy, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Sadiq+MW%22">Sadiq MW</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Fridén+M%22">Fridén M</searchLink>; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Global Product Development, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Hohlfeld+JM%22">Hohlfeld JM</searchLink>; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.; German Center for Lung Research (DZL-BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Disease, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Friberg+LE%22">Friberg LE</searchLink>; Department of Pharmacy, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Svensson+EM%22">Svensson EM</searchLink>; Department of Pharmacy, Uppsala University, Uppsala, Sweden. elin.svensson@uu.se.; Department of Pharmacy, Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands. elin.svensson@uu.se.
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  Data: <searchLink fieldCode="JN" term="%227606849%22">Clinical pharmacokinetics</searchLink> [Clin Pharmacokinet] 2026 Jun 29. <i>Date of Electronic Publication: </i>2026 Jun 29.
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        Value: 10.1007/s40262-026-01664-y
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              Text: 2026 Jun 29
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