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Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features.

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Title: Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features.
Authors: Laidi, C., d'Albis, M.‐A., Wessa, M., Linke, J., Phillips, M. L., Delavest, M., Bellivier, F., Versace, A., Almeida, J., Sarrazin, S., Poupon, C., Le Dudal, K., Daban, C., Hamdani, N., Leboyer, M., Houenou, J.
Source: Acta Psychiatrica Scandinavica. Mar2015, Vol. 131 Issue 3, p223-233. 11p. 1 Color Photograph, 1 Diagram, 3 Charts.
Subjects: Schizophrenia, Psychoses, Schizotypal personality disorder, Echolalia, Mental illness, Cerebellum
Abstract: Objective There is growing evidence that cerebellum plays a crucial role in cognition and emotional regulation. Cerebellum is likely to be involved in the physiopathology of both bipolar disorder and schizophrenia. The objective of our study was to compare cerebellar size between patients with bipolar disorder, patients with schizophrenia, and healthy controls in a multicenter sample. In addition, we studied the influence of psychotic features on cerebellar size in patients with bipolar disorder. Method One hundred and fifteen patients with bipolar I disorder, 32 patients with schizophrenia, and 52 healthy controls underwent 3 Tesla MRI. Automated segmentation of cerebellum was performed using FreeSurfer software. Volumes of cerebellar cortex and white matter were extracted. Analyses of covariance were conducted, and age, sex, and intracranial volume were considered as covariates. Results Bilateral cerebellar cortical volumes were smaller in patients with schizophrenia compared with patients with bipolar I disorder and healthy controls. We found no significant difference of cerebellar volume between bipolar patients with and without psychotic features. No change was evidenced in white matter. Conclusion Our results suggest that reduction in cerebellar cortical volume is specific to schizophrenia. Cerebellar dysfunction in bipolar disorder, if present, appears to be more subtle than a reduction in cerebellar volume. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features.
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  Data: <searchLink fieldCode="AR" term="%22Laidi%2C+C%2E%22">Laidi, C.</searchLink><br /><searchLink fieldCode="AR" term="%22d'Albis%2C+M%2E‐A%2E%22">d'Albis, M.‐A.</searchLink><br /><searchLink fieldCode="AR" term="%22Wessa%2C+M%2E%22">Wessa, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Linke%2C+J%2E%22">Linke, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Phillips%2C+M%2E+L%2E%22">Phillips, M. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Delavest%2C+M%2E%22">Delavest, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bellivier%2C+F%2E%22">Bellivier, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Versace%2C+A%2E%22">Versace, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Almeida%2C+J%2E%22">Almeida, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Sarrazin%2C+S%2E%22">Sarrazin, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Poupon%2C+C%2E%22">Poupon, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Le+Dudal%2C+K%2E%22">Le Dudal, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Daban%2C+C%2E%22">Daban, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Hamdani%2C+N%2E%22">Hamdani, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Leboyer%2C+M%2E%22">Leboyer, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Houenou%2C+J%2E%22">Houenou, J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Mar2015, Vol. 131 Issue 3, p223-233. 11p. 1 Color Photograph, 1 Diagram, 3 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Schizotypal+personality+disorder%22">Schizotypal personality disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Echolalia%22">Echolalia</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellum%22">Cerebellum</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective There is growing evidence that cerebellum plays a crucial role in cognition and emotional regulation. Cerebellum is likely to be involved in the physiopathology of both bipolar disorder and schizophrenia. The objective of our study was to compare cerebellar size between patients with bipolar disorder, patients with schizophrenia, and healthy controls in a multicenter sample. In addition, we studied the influence of psychotic features on cerebellar size in patients with bipolar disorder. Method One hundred and fifteen patients with bipolar I disorder, 32 patients with schizophrenia, and 52 healthy controls underwent 3 Tesla MRI. Automated segmentation of cerebellum was performed using FreeSurfer software. Volumes of cerebellar cortex and white matter were extracted. Analyses of covariance were conducted, and age, sex, and intracranial volume were considered as covariates. Results Bilateral cerebellar cortical volumes were smaller in patients with schizophrenia compared with patients with bipolar I disorder and healthy controls. We found no significant difference of cerebellar volume between bipolar patients with and without psychotic features. No change was evidenced in white matter. Conclusion Our results suggest that reduction in cerebellar cortical volume is specific to schizophrenia. Cerebellar dysfunction in bipolar disorder, if present, appears to be more subtle than a reduction in cerebellar volume. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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