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Mutation rate and genotype variation of Ebola virus from Mali case sequences.

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Title: Mutation rate and genotype variation of Ebola virus from Mali case sequences.
Authors: Hoenen, T., Safronetz, D., Groseth, A., Wollenberg, K. R., Koita, O. A., Diarra, B., Fall, I. S., Haidara, F. C., Diallo, F., Sanogo, M., Sarro, Y. S., Kone, A., Togo, A. C. G., Traore, A., Kodio, M., Dosseh, A., Rosenke, K., de Wit, E., Feldmann, F., Ebihara, H.
Source: Science (pre-March 2025). 4/3/2015, Vol. 348 Issue 6230, p117-119. 3p.
Subjects: Ebola virus, Genetic mutation, Genotypes, Viral genetics, Ebola virus disease, Phylogeny, Virus research, History of Mali -- 1991-, Genetics
Abstract: The occurrence of Ebola virus (EBOV) in West Africa during 2013-2015 is unprecedented. Early reports suggested that in this outbreak EBOV is mutating twice as fast as previously observed, which indicates the potential for changes in transmissibility and virulence and could render current molecular diagnostics and countermeasures ineffective. We have determined additional full-length sequences from two clusters of imported EBOV infections into Mali, and we show that the nucleotide substitution rate (9.6 × 10-4 substitutions per site per year) is consistent with rates observed in Central African outbreaks. In addition, overall variation among all genotypes observed remains low. Thus, our data indicate that EBOV is not undergoing rapid evolution in humans during the current outbreak. This finding has important implications for outbreak response and public health decisions and should alleviate several previously raised concerns. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Mutation rate and genotype variation of Ebola virus from Mali case sequences.
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  Data: <searchLink fieldCode="AR" term="%22Hoenen%2C+T%2E%22">Hoenen, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Safronetz%2C+D%2E%22">Safronetz, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Groseth%2C+A%2E%22">Groseth, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Wollenberg%2C+K%2E+R%2E%22">Wollenberg, K. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Koita%2C+O%2E+A%2E%22">Koita, O. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Diarra%2C+B%2E%22">Diarra, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Fall%2C+I%2E+S%2E%22">Fall, I. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Haidara%2C+F%2E+C%2E%22">Haidara, F. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Diallo%2C+F%2E%22">Diallo, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Sanogo%2C+M%2E%22">Sanogo, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Sarro%2C+Y%2E+S%2E%22">Sarro, Y. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Kone%2C+A%2E%22">Kone, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Togo%2C+A%2E+C%2E+G%2E%22">Togo, A. C. G.</searchLink><br /><searchLink fieldCode="AR" term="%22Traore%2C+A%2E%22">Traore, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Kodio%2C+M%2E%22">Kodio, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Dosseh%2C+A%2E%22">Dosseh, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Rosenke%2C+K%2E%22">Rosenke, K.</searchLink><br /><searchLink fieldCode="AR" term="%22de+Wit%2C+E%2E%22">de Wit, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Feldmann%2C+F%2E%22">Feldmann, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Ebihara%2C+H%2E%22">Ebihara, H.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 4/3/2015, Vol. 348 Issue 6230, p117-119. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Ebola+virus%22">Ebola virus</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+mutation%22">Genetic mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Viral+genetics%22">Viral genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Ebola+virus+disease%22">Ebola virus disease</searchLink><br /><searchLink fieldCode="DE" term="%22Phylogeny%22">Phylogeny</searchLink><br /><searchLink fieldCode="DE" term="%22Virus+research%22">Virus research</searchLink><br /><searchLink fieldCode="DE" term="%22History+of+Mali+--+1991-%22">History of Mali -- 1991-</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink>
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  Label: Abstract
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  Data: The occurrence of Ebola virus (EBOV) in West Africa during 2013-2015 is unprecedented. Early reports suggested that in this outbreak EBOV is mutating twice as fast as previously observed, which indicates the potential for changes in transmissibility and virulence and could render current molecular diagnostics and countermeasures ineffective. We have determined additional full-length sequences from two clusters of imported EBOV infections into Mali, and we show that the nucleotide substitution rate (9.6 × 10-4 substitutions per site per year) is consistent with rates observed in Central African outbreaks. In addition, overall variation among all genotypes observed remains low. Thus, our data indicate that EBOV is not undergoing rapid evolution in humans during the current outbreak. This finding has important implications for outbreak response and public health decisions and should alleviate several previously raised concerns. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=101903707
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        Value: 10.1126/science.aaa5646
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        Text: English
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